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Usage

Uses

Used in Pharmaceutical Industry:
6-oxo-1,6-dihydropyridazine-4-carboxylic acid methyl ester is used as a building block for the synthesis of various pharmaceuticals and organic compounds. It has potential applications in the development of new drugs and therapies.
Used in Research Studies:
6-oxo-1,6-dihydropyridazine-4-carboxylic acid methyl ester has been studied for its potential biological activities and has shown promise in various research studies.

Upstream product

• 617-52-7 Dimethyl itakonate 
• 153895-80-8 methyl 6-oxohexahydropyridazine-4-carboxylate 
• 67-56-1 methanol 
• 867130-58-3 6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid 

Relevant academic research and scientific papers

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid

The present invention provides a process for manufacturing 6-oxo-1 H-pyridazine-4-carboxylic acid 5 comprising - (a) reacting dimethyl 2-methylenebutanedioate with hydrazine to obtain methyl 6- oxohexahydropyridazine-4-carboxylate 11; - (b) oxidizing methyl 6-oxohexahydropyridazine-4-carboxylate 11 with a suitable oxidizing agent to methyl 6-oxo-1 H-pyridazine-4-carboxylate 4a; - (c) isolating methyl 6-oxo-1 H-pyridazine-4-carboxylate 4a; - (d) hydrolyzing methyl 6-oxo-1 H-pyridazine-4-carboxylate 4a in the presence of an aqueous base or acid to the 6-oxo-1 H-pyridazine-4-carboxylic acid 5.