896462-34-3

Usage

Uses

Used in Pharmaceutical Industry:
(1-Phenylpyrrolidin-2-yl)methanol is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications. Its unique molecular structure allows it to be a versatile component in the creation of diverse medicinal compounds.
Used in Organic Synthesis:
(1-Phenylpyrrolidin-2-yl)methanol serves as a building block in organic synthesis, enabling the construction of complex organic molecules. Its presence in the synthesis process can lead to the formation of a wide range of organic compounds with various applications.
Used as a Chiral Resolving Agent:
(1-Phenylpyrrolidin-2-yl)methanol has been studied for its potential use as a chiral resolving agent. In this capacity, it can help in the separation of enantiomers, which is crucial in the production of pure chiral compounds, particularly in the pharmaceutical sector where the efficacy and safety of a drug can be highly dependent on its stereochemistry.

Upstream product

• 108-86-1 bromobenzene 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 147-85-3 L-proline 
• 139983-29-2 (S)-1-phenylpyrrolidine-2-carboxylic acid 
• 146500-37-0 N-phenyl-L-proline methyl ester 

Downstream Products

• 1244607-22-4 C₁₂H₁₆N₂O₃ 
• 1315457-05-6 C₁₁H₁₄BrN 
• 896462-48-9 (S)-2-(benzyloxymethyl)-1-(2-bromophenyl)pyrrolidine 
• 896462-45-6 (S)-1-(2-bromophenyl)-2-(methoxymethyl)pyrrolidine 
• 896462-42-3 (3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene 
• 896462-37-6 (S)-(1-(2-bromophenyl)pyrrolidin-2-yl)methanol 
• 1260154-72-0 C₁₈H₁₇NO₃ 

Relevant academic research and scientific papers

BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN

Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Compounds and uses thereof for the modulation of hemoglobin

Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Imidazole-coordinated monodentate NHC-Pd(II) complex derived from proline and its application to the coupling reaction of arylboronic acids with carboxylic acid anhydrides in water at room temperature

Cleavage of a C-N bond of imidazolium salt derived from N-phenyl-substituted proline was observed in this laboratory. A novel imidazole-coordinated monodentate NHC-Pd(II) complex 5 was obtained as the sole product in good yield in the reaction of imidazolium salt 4 with Pd(OAc) 2 in refluxing THF. The structure of complex 5 was determined unambiguously by an X-ray diffraction. The complex was found to be a good catalyst in the cross-coupling reaction of arylboronic acids with carboxylic acid anhydrides in water at room temperature. Copyright

Preparation of N-phenyl-(S)-prolinol-derived P,N-ligands and their application in Pd-catalyzed asymmetric allylic alkylation

Several NPN-type ligands bearing two chiral pyrrolidinyl groups derived from N-phenyl-(S)-prolinol were prepared by two synthetic methods. Their palladium-complex-catalyzed asymmetric allylic alkylation of malonates with 1,3-diphenyl 2-propenyl acetate delivered the products with good to high enantioselectivities (84-97% ee), including an optically active fluorine-containing compound.