896462-37-6

Basic information

• Product Name: (S)-(1-(2-bromophenyl)pyrrolidin-2-yl)methanol
• Synonyms: (S)-(1-(2-bromophenyl)pyrrolidin-2-yl)methanol
• CAS NO: 896462-37-6
• Molecular Weight: 256.142
• Mol File: 896462-37-6.mol

Chemical Properties

• CAS DataBase Reference: (S)-(1-(2-bromophenyl)pyrrolidin-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(1-(2-bromophenyl)pyrrolidin-2-yl)methanol(896462-37-6)
• EPA Substance Registry System: (S)-(1-(2-bromophenyl)pyrrolidin-2-yl)methanol(896462-37-6)

Safety Data

• Hazardous Substances Data: 896462-37-6(Hazardous Substances Data)

Upstream product

• 146500-37-0 N-phenyl-L-proline methyl ester 
• 147-85-3 L-proline 
• 139983-29-2 (S)-1-phenylpyrrolidine-2-carboxylic acid 
• 108-86-1 bromobenzene 
• 583-55-1 1-Bromo-2-iodobenzene 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 896462-34-3 ((S)-1-phenylpyrrolidin-2-yl)methanol 

Downstream Products

• 896462-45-6 (S)-1-(2-bromophenyl)-2-(methoxymethyl)pyrrolidine 
• 896462-48-9 (S)-2-(benzyloxymethyl)-1-(2-bromophenyl)pyrrolidine 

Relevant articles and documents

Chiral P,O-ligands derived from N,O-phenylene prolinols for palladium-catalyzed asymmetric allylic alkylation

CuI-catalyzed N,O-arylation of (S)-prolinols and 1-bromo-2-iodobenzene afforded cyclic N,O-(1,2-phenylene)prolinols, and subsequent ortho-lithiation and phosphination provided a new type of chiral P,O-ligands. Their palladium-complex-catalyzed asymmetric

Preparation of N-phenyl-(S)-prolinol-derived P,N-ligands and their application in Pd-catalyzed asymmetric allylic alkylation

Several NPN-type ligands bearing two chiral pyrrolidinyl groups derived from N-phenyl-(S)-prolinol were prepared by two synthetic methods. Their palladium-complex-catalyzed asymmetric allylic alkylation of malonates with 1,3-diphenyl 2-propenyl acetate delivered the products with good to high enantioselectivities (84-97% ee), including an optically active fluorine-containing compound.