89649-42-3Relevant academic research and scientific papers
INHIBITORS OF METALLO-BETA-LACTAMASES
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Paragraph 00151; 00152, (2018/12/13)
The present invention relates to compounds of Formula (I) that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection. (Formula (I))
Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines
Collot, Valerie,Schmitt, Martine,Marwah, Padma,Bourguignon, Jean-Jacques
, p. 2823 - 2847 (2007/10/03)
The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quantitative C-2 epimerization.
Synthesis of 3-phenylindoline-2-carboxamides as semi-rigid phenylalanine mimetics
Collot, Valerie,Schmitt, Martine,Marwah, Ashok K.,Norberg, Bernadette,Bourguignon, Jean-Jacques
, p. 8033 - 8036 (2007/10/03)
Regioselective catalytic hydrogenation of N-acyl 3-phenylindole-2-carboxylates is the key step for tile preparation of cis and trans ndoline-2-carboxamides which can be considered as phenylalanine semi-rigid derivatives.
A new and practical synthesis of pyrroles
Quiclet-Sire, Beatrice,Thevenot, Isabelle,Zard, Samir Z.
, p. 9469 - 9470 (2007/10/02)
Heating γ-nitroketones bearing an electron-withdrawing group such as an ester germinal to the nitro group with formamidinesulfinic acid and triethylamine in isopropanol produces pyrroles in good yield.
Porphyrins with Exocyclic Rings. 1. Chemistry of 4,5,6,7-Tetrahydro-1H-indoles: Synthesis of Acetoxy Derivatives, Dihydroindoles, and Novel Porphyrins with Four Exocyclic Rings
Lash, Timothy D.,Bladel, Karla A.,Shiner, Craig M.,Zajeski, Donna L.,Balasubramaniam, Rajiv P.
, p. 4809 - 4820 (2007/10/02)
A variety of 4,5,6,7-tetrahydro-1H-indoles (THI's) and 4-oxo-4,5,6,7-tetrahydro-1-indoles (4-oxoTHI's) have been synthesized from cyclohexanone and 1,3-cyclohexanedione, respectively.The THI's reacted regioselectively with lead tetraacetate in acetic acid
The Synthesis and Chemistry of Azolenines. Part 2. A General Synthesis of Pyrrole-2-carboxylic Acid Derivatives by the Reaction of 2H-Azirines with Enamines, and the Crystal and Molecular Structure of Ethyl 3-Phenyl-4,5,6,7-tetrahydroindole-2-carboxylate
Law, Kam Wah,Lai, Ting-Fong,Sammes, Michael P.,Katritzky, Alan R.,Mak, Thomas C.W.
, p. 111 - 118 (2007/10/02)
A new general synthesis of 1H-pyrrole-2-carboxylic acid derivatives is described.Reaction between appropriately substituted 2H-azirines and enamines gives a mixture of 2,3- and 3,4-dihydropyrroles, which on acid treatment yields the title compounds in mod
