896720-63-1

Upstream product

• 621-03-4 cyanoacetanilide 
• 24721-26-4 4-chlorochalcone 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 59749-96-1 3-amino-3-thioxo-N-phenylpropanamide 

Downstream Products

• 896720-64-2 2-bromo-4-(4-chlorophenyl)-6-phenyl-N-phenyl-3-pyridinecarboxamide 

Relevant academic research and scientific papers

Unusual Michael reaction of 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one with 3-amino-N-phenyl-3-thioxopropanamide

3-(4-Chlorophenyl)-1-phenylprop-2-en-1-one reacted with 3-amino-N-phenyl-3-thioxopropanamide under basic conditions in ethanol to give a mixture of 3-(4-chlorophenyl)-2-cyano-5-oxo-N,5-diphenylpentanamide and 3-(4-chlorophenyl)-1,5-diphenylpentane-1,5-dione. The structure of the former was determined by X-ray analysis. The reaction of the same compounds in DMSO in the presence of sodium hydroxide produced 4-(4-chlorophenyl)-N,6-diphenyl-2- thioxo-1,2,3,4-tetrahydropyridine-3-carboxamide.

Novel synthesis of nicotinamide derivatives of cytotoxic properties

A variety of 2-substituted-4,6-diaryl-3-pyridinecarboxamides 5 were synthesized through aromatic nucleophilic substitution reaction of secondary amines with 2-bromo analogues 4. The latter were obtained via bromination of 2-cyano-3,5-diaryl-5-oxo-N-substi