89677-35-0Relevant academic research and scientific papers
First synthesis of nitrosporeusines, alkaloids with multiple biological activities
Philkhana, Satish Chandra,Jachak, Gorakhnath R.,Gunjal, Vidya B.,Dhage, Nagsen M.,Bansode, Ajay H.,Reddy, D. Srinivasa
, p. 1252 - 1254 (2015)
Synthesis of nitrosporeusines A and B, thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus with exceptional biological activity is disclosed for the first time. In addition, we have prepared another biologically important natural product
Identification of new anti-inflammatory agents based on nitrosporeusine natural products of marine origin
Philkhana, Satish Chandra,Verma, Abhishek Kumar,Jachak, Gorakhnath R.,Hazra, Bibhabasu,Basu, Anirban,Reddy, D. Srinivasa
, p. 89 - 109 (2017/04/26)
Nitrosporeusines A and B are two recently isolated marine natural products with novel skeleton and exceptional biological profile. Interesting antiviral activity of nitrosporeusines and promising potential in curing various diseases, evident from positive data from various animal models, led us to investigate their anti-inflammatory potential. Accordingly, we planned and synthesized nitrosporeusines A and B in racemic as well as enantiopure forms. The natural product synthesis was followed by preparation of several analogues, and all the synthesized compounds were evaluated for in vitro and in vivo anti-inflammatory potential. Among them, compounds 25, 29 and 40 significantly reduced levels of nitric oxide (NO), reactive oxygen species (ROS) and pro-inflammatory cytokines. In addition, these compounds suppressed several pro-inflammatory mediators including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-κB (NF-κB), and thereby can be emerged as potent anti-inflammatory compounds. Furthermore, all possible isomers of lead compound 25 were synthesized, characterized and profiled in same set of assays and found that one of the enantiomer (?)-25a was superior among them.
BENZENECARBOTHIOCCYCLOPENTA[C] PYRROLE-1,3-DIONE COMPOUNDS AND PROCESS FOR SYNTHESIS THEREOF
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Page/Page column 16, (2016/04/26)
The present invention relates to a novel analogues of benzenecarbothioccyclopenta[c]pyrrole-1,3-dione of formula (I) useful for treating various viral infections and process for synthesis thereof. The present invention provides a novel process for synthes
Antibacterial 7-oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene derivatives
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, (2008/06/13)
A compound of the formula I STR1 in which R1 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, the --CONHR1 group being present at the 3- or 4-position on the phenyl ring, and esters thereof at the 2-carbo
