897019-59-9

Usage

Uses

Used in Pharmaceutical Research:
3-(Benzyloxy)azetidine benzenesulfonate is used as a building block for the synthesis of various drugs and biologically active compounds, leveraging its structural properties to contribute to the development of new medications.
Used as a Chiral Auxiliary:
In the field of organic synthesis, 3-(Benzyloxy)azetidine benzenesulfonate is utilized as a chiral auxiliary, which is instrumental in the creation of enantiomerically pure molecules. This application is crucial for ensuring the desired biological activity and minimizing potential side effects in pharmaceuticals.
Used in Drug Discovery:
3-(BENZYLOXY)AZETIDINE BENZENESULFONATE's potential pharmacological properties make 3-(Benzyloxy)azetidine benzenesulfonate a valuable asset in drug discovery processes, where it can be explored for its therapeutic effects and incorporated into novel drug formulations.
Used in Organic Synthesis Industry:
3-(Benzyloxy)azetidine benzenesulfonate is employed as a key intermediate in the organic synthesis industry, where its unique structure and reactivity contribute to the production of a wide range of chemical products, including specialty chemicals and complex organic molecules.

Upstream product

• 100-39-0 benzyl bromide 
• 1027995-71-6 3-(benzyloxy)azetidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1383372-04-0 N-(4-(3-(benzyloxy)azetidine-1-carbonyl)phenyl)quinoline-8-sulfonamide 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND, APPLICATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Disclosed in the present invention are a heterocyclic compound, an application thereof and a pharmaceutical composition comprising the same. Provided by the present invention are a heterocyclic compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound has a novel structure and a good inhibitory activity against autotaxin (ATX).

Synthesis of Diverse N-Acryloyl Azetidines and Evaluation of Their Enhanced Thiol Reactivities

Acyl azetidines exhibit nonplanar hybridization, leading to lower amide-like character of the corresponding (O)C-N bonds. This impacts N-acryloyl azetidines by producing enhanced electrophilicy at appended Michael acceptors. Herein, reactivity data are reported in the presence of glutathione (GSH) in phosphate buffer (pH 7.4) at 37 °C. Wide reactivity ranges are observed by varying substitution at the Michael acceptor or by modulating the electron-withdrawing character of substituents at the C3 position of the azetidine.

BENZAZEPINE DICARBOXAMIDE COMPOUNDS WITH TERTIARY AMIDE FUNCTION

This invention relates to new benzazepine dicarboxamide compounds of the formula (I) wherein R1 to R 3 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.

Methods of using pyruvate kinase activators

Described herein are methods for using compounds that activate pyruvate kinase.

NOVEL N- (4- (AZETIDINE - 1 - CARBONYL) PHENYL) - (HETERO - ) ARYLSULFONAMIDE DERIVATIVES AS PYRUVATE KINASE M2 (PMK2) MODULATORS

Compounds of general Formula (I), and compositions comprising compounds of general formula I that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of canc

NOVEL HETEROCYCLIC ACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS

The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.

AZETIDINE-SUBSTITUTED PYRAZOLINES AS PAR-1 ANTAGONISTS

The invention relates to blood clotting, and especially to the use of azetidine-substituted pyrazolines as medicaments, novel azetidine-substituted pyrazolines, methods for the production thereof, and the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases, preferably thromboembolic diseases.