897027-52-0Relevant academic research and scientific papers
Microwave preparation method of 2, 4-disubstituted oxazole compound
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Paragraph 0015; 0017; 0021, (2020/11/25)
The invention discloses a microwave preparation method of a 2, 4-disubstituted oxazole compound. The method comprises the following steps: carrying out heating reflux reaction on substituted carboxylic acid and thionyl chloride, after the reaction is finished, carrying out rotary evaporation to remove excessive thionyl chloride to obtain yellow transparent liquid substituted acyl chloride, and then adding dichloromethane to dilute for later use; dropwise adding substituted acyl chloride into ammonia water while stirring under an ice bath condition, removing the ice bath after the acyl chlorideis dropwise added, stirring at room temperature until a large amount of white solids appear in the solution, carrying out suction filtration after the reaction is finished, and drying to obtain substituted amide. Substituted amide, dichloromethane, triethylamine and an alpha-bromocarbonyl compound are loaded into a pressure reaction tank designed by CEM. The mixture is irradiated in a CEM DISCOVER 2.0 annular focusing single-mode microwave synthesizer. The mixture is cooled to room temperature by passing compressed air through a microwave chamber. The target compound is filtered after cooling, and the crude solid recrystallized with ethanol to obtain the 2, 4-disubstituted oxazole compound.
Divergent Palladium-Catalyzed Tandem Reaction of Cyanomethyl Benzoates with Arylboronic Acids: Synthesis of Oxazoles and Isocoumarins
Chen, Jiuxi,Chen, Zhongyan,Dai, Ling,Shao, Yinlin,Xiong, Wenzhang,Xu, Tong,Yu, Shuling
, (2020/04/15)
A palladium-catalyzed tandem reaction of cyanomethyl benzoates with arylboronic acids has been achieved. Substitution at the 2-position of cyanomethyl benzoates was found to be crucial for the selective synthesis of oxazoles and isocoumarins. Cyanomethyl
Radical cascade synthesis of azoles: via tandem hydrogen atom transfer
Chen, Andrew D.,Herbort, James H.,Mustafa, Darsheed N.,Nagib, David A.,Nakafuku, Kohki M.,Wappes, Ethan A.
, p. 2479 - 2486 (2020/03/19)
A radical cascade strategy for the modular synthesis of five-membered heteroarenes (e.g. oxazoles, imidazoles) from feedstock reagents (e.g. alcohols, amines, nitriles) has been developed. This double C-H oxidation is enabled by in situ generated imidate
Suzuki coupling of oxazoles
Flegeau, Emmanuel Ferrer,Popkin, Matthew E.,Greaney, Michael F.
, p. 2495 - 2498 (2007/10/03)
A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excel
