89718-75-2Relevant academic research and scientific papers
One-pot, diversity-oriented synthesis of aryl-substituted benzoxacycles including benzofuran, coumarin, and benzoxazepine
Masui, Hisashi,Ohkawa, Eri,Kitahara, Rika,Wanibuchi, Kiyofumi,Takahashi, Takashi
, p. 2273 - 2290 (2017/12/12)
A one-pot method for the synthesis of benzoxacycles including benzofuran, coumarin, benzoxazepine, and benzoxazocine from a common synthetic intermediate was established. Benzoxacycles are privileged structures in medicinal chemistry and have featured in several clinically used drugs. The synthesis of a benzofuran containing an aryl substituent was accomplished using potassium carbonate and sodium hydride. The one-pot synthesis of coumarin was also carried out using trans-decalin as the solvent. The optimized conditions for the one-pot synthesis of benzoxazepine can also be applied to the synthesis of benzoxazocine.
Synthesis of 5-Aryl-1,4-benzoxazepine and 6-Phenyl-2H-1,5-benzoxazocine Derivatives
Bremner, John B.,Browne, Elaine J.,Gunawardana, Indrani W. K.
, p. 129 - 141 (2007/10/02)
Four 5-aryl-2,3-dihydro-1,4-benzoxazepines (5a-d), with electron-releasing substituents, were prepared by a Bischler-Napieralski-type reaction of N-(2-aryloxyethyl)benzamides with phosphorus oxychloride in butanenitrile or ethanenitrile.Analogous 2,3-dihy
