89728-15-4Relevant academic research and scientific papers
First demonstration of positive allosteric-like modulation at the human wild type translocator protein (TSPO)
Narlawar, Rajeshwar,Werry, Eryn L.,Scarf, Alana M.,Hanani, Raphy,Chua, Sook Wern,King, Victoria A.,Barron, Melissa L.,Martins, Ralph N.,Ittner, Lars M.,Rendina, Louis M.,Kassiou, Michael
, p. 8743 - 8749 (2015/11/25)
We show that changing the number and position of nitrogen atoms in the heteroatomic core of a pyrazolopyrimidine acetamide is sufficient to induce complex binding to wild type human TSPO. Only compounds with this complex binding profile lacked intrinsic effect on glioblastoma proliferation but positively modulated the antiproliferative effects of a synthetic TSPO ligand. To the best of our knowledge this is the first demonstration of allosteric-like interaction at the wild type human TSPO.
N-pyridinyl(alkyl)polyhalogenobenzamides acting as TNF-α production inhibitors
Collin,Robert,Robert,Le Baut,Bobin-Dubigeon,Grimaud,Lang,Petit
, p. 233 - 238 (2007/10/03)
A series of N-pyridinyl(methyl)fluorobenzamides issued from 2,4-dimethyl-6-aminopyridine and 3-aminomethylpyridine were synthesized and evaluated as inhibitors of TNF-α production. Although less active than the corresponding phthalimides, several pentaflu
PYRIDYL IMIDAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
-
, (2008/06/13)
Substituted pyridyl imidazole derivatives of formula (I) inhibit effectively the action of angiotensin II and have a superior anti-hypertensive activity. STR1
Diaminopyridine compounds and methods of use
-
, (2008/06/13)
The present invention relates to compositions and method for inhibiting nonenzymatic cross-linking (protein aging) which contain diaminopyridines and derivates thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
