897545-07-2Relevant academic research and scientific papers
5-Quinoline derivatives having an anti-bacterial activity
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Page/Page column 17, (2010/12/31)
The present invention describes novel anti-bacterial compounds of the formula (I). These compounds are, amongst others, of interest as inhibitors of DNA gyrase and topoisomerases, for example of topoisomerase II and IV.
A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: Discovery of a potential atypical antipsychotic agent
Belliotti, Thomas R.,Wustrow, David J.,Brink, Wouter A.,Zoski, Kim T.,Shih, Yu-Hsin,Whetzel, Steven Z.,Georgic, Lynn M.,Corbin, Ann E.,Akunne, Hyacinth C.,Heffner, Thomas G.,Pugsley, Thomas A.,Wise, Lawrence D.
, p. 5181 - 5187 (2007/10/03)
As part of a program to develop dopamine D4 antagonists for the treatment of schizophrenia, we discovered a series of 6- and 7- (phenylpiperazinyl)- and -(phenylpiperidinyl)methylbenzoxazinones through mass screening of our compound library. A structure-a
