898053-27-5Relevant academic research and scientific papers
Pyrazole N-alkylation method
-
Paragraph 0033; 0034, (2018/12/14)
The invention provides a pyrazole N-alkylation method. Pyrazole or pyrazole derivatives and alkyl halogenated hydrocarbons react in a solvent under the existence of quaternary ammonium salt catalysts;N-alkyl substituted pyrazole is obtained. The method provided by the invention has the advantages that the operation is simple; the cost is low; the anhydrous oxygen-free environment is not needed; heating is not needed; the yield is high; the amplified industrialized production can be easily realized.
Regioselective Synthesis, NMR, and Crystallographic Analysis of N1-Substituted Pyrazoles
Huang, Adrian,Wo, Kellie,Lee, So Yeun Christine,Kneitschel, Nika,Chang, Jennifer,Zhu, Kathleen,Mello, Tatsiana,Bancroft, Laura,Norman, Natalie J.,Zheng, Shao-Liang
, p. 8864 - 8872 (2017/09/11)
A systematic study of the N-substitution reactions of 3-substituted pyrazoles under basic conditions has been undertaken. Regioselective N1-alkylation, -arylation, and -heteroarylation of 3-substituted pyrazoles have been achieved using K2CO3-DMSO. The regioselectivity is justified by the DFT calculations at the B3LYP/6-31G??(d) level. A consistent steric effect on chemical shift has been observed for N-alkyl pyrazole analogues. Twenty-five X-ray crystallographic structures have been obtained to confirm the regiochemistry of the major products.
SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME
-
Page/Page column 136, (2016/09/15)
ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.
Benzyl-1H-pyrazole and benzyl-1H-pyrazole derivatives, and preparation method and application thereof
-
Paragraph 0069; 0070; 0071; 0072; 0085; 0086; 0087; 0088, (2016/10/09)
The invention belongs to the field of chemical medicine, and particularly relates to benzyl-1H-pyrazole and benzyl-1H-pyrazole derivatives, and a preparation method and application thereof. The structure of the benzyl-1H-pyrazole and benzyl-1H-pyrazole de
