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• 141-97-9 ethyl acetoacetate 
• 104-88-1 4-chlorobenzaldehyde 
• 109-77-3 malononitrile 
• 89809-77-8 ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate 
• 107-91-5 cyanoacetic acid amide 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 19310-60-2 (E)-2-cyano-3-(4-chlorophenyl)-2-propenamide 
• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 

Relevant academic research and scientific papers

Study of supramolecular self-assembly of pyridone and dihydropyridone co-crystal: Synthesis, crystal structure, Hirshfeld surface, DFT and molecular docking studies

Dihydropyridone is synthesized by the multicomponent condensation reactions (MCRs), followed by three different oxidation methods to synthesize pyridone. The 3-D self-assemblies of both the compounds were determined using the single-crystal X-ray diffraction method. Dihydropyridone products are found as a racemic mixture in synthesis and crystalized as co-crystal. Similar structural conformations are observed in both the compounds but stabilized with different non-covalent interactions. Hirshfeld surface analysis is done to analyze the various intermolecular interactions in both the structure. This study gives the clue of driving force in the self-assembly of molecules in crystal lattices. The propensity of inter-molecular contacts to construct the supramolecular assembly was further studied using DFT. The geometrical optimizations of both the compounds were done by the electronic structure method using density functional theory (DFT) to identify the active sites and explore the molecules' chemically reactive parameters. Further, both compounds were docked with Survivin Protein and Kinesin Eg5 protein to analyze the binding affinity with targeted protein.

Synthesis of 3,4-dihydropyridin-2-one derivatives in convergent mode applying bio catalyst vitamin B1 and polymer supported catalyst PEG-SO3H from two different sets of building blocks

Two highly efficient, green protocols have been developed for the synthesis of 3,4-dihydropyridin-2-one derivatives from different starting materials exploring two reaction specific catalysts, vitamin B1 (VB 1), and PEG-SO3/sub

Nano crystalline ZnO catalyzed one pot multicomponent reaction for an easy access of fully decorated 4H-pyran scaffolds and its rearrangement to 2-pyridone nucleus in aqueous media

A green and highly efficient protocol has been developed for the synthesis of 4H-pyran scaffolds installing a one-pot three-component coupling reaction of an aldehyde, malononitrile, and a 1,3-diketo compound using nano structured ZnO as the catalyst in a

ZnO nanoparticles: An efficient reagent, simple and one-pot procedure for synthesis of highly functionalized dihydropyridine derivatives

A new and efficient one-pot synthesis of dihydropyridones derivatives by four-component reaction between cyanoacetamide, aryl aldehydes, and ethyl acetoacetate with ammonium acetate using nano ZnO is described. The reaction was performed in ethanol under reflux conditions and afforded good yields of products.

REACTIONS OF SIX-MEMBERED HETEROCYCLIC β-ENAMINONITRILES WITH ELECTROPHILIC REAGENTS

The nitriles I reacted with acetylacetone and with ethyl acetoacetate to afford 2-amino-3-cyano-4H-pyran derivatives.They reacted further to yield pyranopyridine derivatives.The reaction of V with acetylacetone afforded the pyridinethione VIII.This afford

SYNTHESIS AND STRUCTURE OF SUBSTITUTED 3,4-DIHYDROPYRIDIN-2-ONES

The condensation of benzylideneacetoacetic ester with cyanoacetamide in the presence of triethylamine yielded 3-carbamoyl-3,4-dihydropyridin-2-one, while the condensation of arylidenecyanoacetamides with β-aminocrotonic ester in acetic acid yielded 3-cyano-3,4-dihydropyridin-2-ones.It was established by NMR spectroscopy that 3-cyano-4-R-5-ethoxycarbonyl-6-methyl-3,4-dihydropyridin-2-ones exist in solutions in the form of a mixture of cis- and trans-stereosiomers in a 10:1 ratio.