898162-35-1Relevant academic research and scientific papers
Visible light induced the high-efficiency spirocyclization reaction of propynamide and thiophenols via recyclable catalyst Pd/ZrO2
Zhang, Nannan,Zuo, Hangdong,Xu, Chen,Pan, Junyi,Sun, Jun,Guo, Cheng
, p. 337 - 340 (2020)
A new method for the synthesis of 3-thioazaspiro[4,5]trienones was developed using Pd nanoparticle catalysts, which are highly efficient, environmentally friendly and recyclable. Alkynes and thiophene phenols are effectively cyclized by Pd/ZrO2
Synthesis of alkynamides through reaction of alkyl- or aryl-substituted alkynylaluminums with isocyanates
Cho, Soohong,Lee, Yeonjoo,Lee, Kyeongmin,Lee, Hwiwoong,Lee, Yunmi,Jung, Byunghyuck
, p. 139 - 151 (2021/12/29)
An efficient and facile method for the preparation of alkynamides through Et3N-catalyzed alumination of alkyl- or aryl-substituted terminal alkynes with AlMe3and sequential nucleophilic addition ofin situgenerated alkynylaluminums to isocyanates is described. This method has the merits of using readily available isocyanates and monosubstituted alkynes, easy access to organoaluminums, short reaction times, and high efficiency. A gram-scale synthesis of the desired alkynamide and its application to the formation of α-methylene-β-lactams demonstrates the synthetic utility of this method.
Copper-catalyzed difunctionalization of activated alkynes by radical oxidation-tandem cyclization/dearomatization to synthesize 3-trifluoromethyl spiro[4.5]trienones
Hua, Hui-Liang,He, Yu-Tao,Qiu, Yi-Feng,Li, Ying-Xiu,Song, Bo,Gao, Pin,Song, Xian-Rong,Guo, Dong-Hui,Liu, Xue-Yuan,Liang, Yong-Min
supporting information, p. 1468 - 1473 (2015/01/30)
A copper-catalyzed difunctionalizing trifluoromethylation of activated alkynes with the cheap reagent sodium trifluoromethanesulfinate (NaSO2CF3 or Langlois' reagent) has been developed incorporating a tandem cyclization/ dearomatiza
2,5-diarylisothiazolone: Novel inhibitors of cytokine-induced cartilage destruction
Wright, Stephen W.,Petraitis, Joseph J.,Freimark, Bruce,Giannaras, John V.,Pratta, Michael A.,Sherk, Susan R.,Williams, Jean M.,Magolda, Ronald L.,Arner, Elizabeth C.
, p. 851 - 858 (2007/10/03)
A series of 2,5-diarylisothiazolones is reported that inhibit the IL-1β- induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, n
