89830-98-8Relevant articles and documents
NOVEL APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS
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Page/Page column 46, (2021/01/23)
The present invention relates to inhibitors of apoptosis signal-regulating kinase 1 ("ASK1"), a process for synthesis of the compounds of the present invention, composition comprising the compounds and use of the compounds for inhibition of ASK1.
ASK1 inhibitor and application thereof
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Paragraph 0188-0191, (2020/02/10)
The invention relates to compounds represented by a general formula (I) shown in the specification, a pharmaceutically acceptable salt and ester, or a stereoisomer of the compounds. The invention alsorelates to a preparation method of the compounds, a pharmaceutical preparation and a pharmaceutical composition containing the compounds. The compounds provided by the invention can effectively inhibit the amino acid phosphorylation of ASK1 and inhibit the activation of the ASK1; therefore, the compounds can treat and/or prevent ASK1-mediated diseases and related diseases.
Substituted triazole compound, pharmaceutical composition containing substituted triazole compound, preparation method and application of substituted triazole compound
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Paragraph 0191-0193, (2020/01/25)
The present invention relates to a substituted triazole compound represented by formula (I), a pharmaceutical compositions comprising the substituted triazole compound, a preparation method of the substituted triazole compound, and applications of the sub
ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF
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, (2020/01/02)
The present disclosure relates to a compound as shown in formula (II), a tautomer or a pharmaceutically acceptable salt thereof, and disclosed is the use thereof in preparing a drug for treating an ASK1-associated disease.
Novel ASK1 inhibitor and application thereof
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Paragraph 0121-0124; 0176-0179; 0217-0220, (2019/10/15)
The invention relates to a compound shown as a general formula (I), a pharmacologically acceptable salt, ester or a stereisomer. The invention also relates to a preparation method of the compound, a medicine preparation containing the compound and a medic
PYRIDINYL BASED APOPTOSIS SIGNAL-REGULATION KINASE INHIBITORS
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, (2018/09/12)
Apoptosis signal-regulating kinase 1 (ASK1) activation and signaling have been reported to play an important role in a broad range of diseases including neurodegenerative, cardiovascular, inflammatory, autoimmunity and metabolic disorders. Disclosed herein is the synthesis of pyridinyl derived therapeutic agents that function as inhibitors of ASK 1 as well as their pharmaceutical compositions and methods of use.
PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
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Page/Page column 16, (2013/05/23)
The present invention relates to purine derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS
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Page/Page column 30, (2011/02/15)
The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. T
DISUBSTITUTED IMIDAZOLE DERIVATIVES AS MODULATORS OF RAF KINASE
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Page/Page column 64; 66, (2010/09/18)
Novel substituted imidazole compounds, compositions containing them, and methods of using them for the inhibition of Raf kinase activity are provided. The new compounds and compositions may be used either alone or in combination with an additional agent f
AMIDES AS KINASE INHIBITORS
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Page/Page column 34; 35, (2010/09/17)
The present invention is directed to amides, and pharmaceutical compositions thereof, which are inhibitors of kinases such as BCR AbI, FLT3, c-Kit, KDR, LCK, Epha2 and PDGFR subfamily and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.