1448428-03-2

Basic information

• Product Name: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride
• Synonyms: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride
• CAS NO: 1448428-03-2
• Molecular Weight: 296.729
• Mol File: 1448428-03-2.mol

Chemical Properties

• CAS DataBase Reference: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride(1448428-03-2)
• EPA Substance Registry System: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride(1448428-03-2)

Safety Data

• Hazardous Substances Data: 1448428-03-2(Hazardous Substances Data)

Upstream product

• 89830-98-8 4-cyclopropyl-1H-imidazole 
• 1448508-47-1 5-(4-cyclopropyl-1H-imidazole-1-yl)-2-fluoro-4-methylbenzoic acid 
• 81447-28-1 2-cyclopropyl-2-oxoethyl 4-methylbenzenesulfonate 
• 765-43-5 Cyclopropyl methyl ketone 
• 1448428-02-1 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile 
• 1448428-01-0 5-(4-cyclopropyl-2-mercapto-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile 
• 1448428-00-9 5-((2-cyclopropyl-2-oxoethyl)amino)-2-fluoro-4-methylbenzonitrile 
• 1426136-04-0 5-amino-2-fluoro-4-methylbenzonitrile 
• 627871-16-3 5-bromo-4-fluoro-2-methylaniline 

Downstream Products

• 1448428-05-4 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide 
• 1448428-04-3 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide 

Relevant articles and documents

APOPTOSIS SIGNAL-REGULATING KINASE INHIBTOR

Provided is a compound of Formula (I) or a pharmaceutically acceptable salt thereof for use in treatment of non-alcoholic steatohepatitis, alcoholic hepatitis, pulmonary arterial hypertension, heart failure with preserved ejection fraction, and diabetic k

PROCESSES FOR PREPARING ASK1 INHIBITORS

The present disclosure provides processes for the preparation of a compound of formula (A) which exhibits apoptosis signal-regulating kinase ("ASK1") inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.

APOPTOSIS SIGNAL-REGULATING KINASE INHIBITOR

The present invention relates to a compound of formula (I): The compound has apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.