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Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activity and versatility in drug design.
Used in Antiviral Applications:
In the field of antiviral research, 4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile is used as a drug candidate for its potential to inhibit viral replication and reduce the severity of viral infections.
Used in Antifungal Applications:
4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile is employed as an antifungal agent, targeting the inhibition of fungal growth and helping in the treatment of various fungal infections.
Used as an Enzyme Inhibitor:
In medicinal chemistry research, 4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile is utilized as an inhibitor of certain enzymes, playing a crucial role in the regulation of biological processes and the development of enzyme-targeted therapies.
Overall, 4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile is a valuable compound in the pharmaceutical and medicinal chemistry fields, with diverse applications ranging from drug synthesis to therapeutic interventions against viral and fungal infections, as well as enzyme inhibition.

Upstream product

• 867-44-7 S-Methylisothiourea sulfate 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 147895-43-0 S-methylisothiourea hemisulphate 

Downstream Products

• 1208170-17-5 4-chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile 
• 1208169-85-0 2-((3-amino-2-hydroxypropyl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1208169-80-5 2-((3-amino-2,2-dimethylpropyl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1208169-75-8 2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1208169-91-8 (R)-2-(piperidin-3-ylamino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1208170-04-0 4-[(3-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1208170-21-1 1,1-dimethylethyl [3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate 

Relevant academic research and scientific papers

An efficient and practical synthesis of 2,4-substituted pyrido[4,3-d]pyrimidin-5(6H)-ones

We describe an efficient synthesis of 2,4-substituted pyrido[4,3-d]pyrimidin-5(6H)-ones, which involves the acid-promoted cyclization of cyano enamine 15 to afford 2,4-bis(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 17 as a key intermediate. Selective displacement of the 4-methylthio group by a wide range of anilines followed by oxidation of the 2-methylthio group and subsequent substitution by amines enabled the synthesis of a variety of 2,4-disubstituted pyrido[4,3-d]pyrimidin-5(6H)-ones.

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R1, R2, R3, X, Y, Z, A, B, G1, m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R1, R2, R3, X, Y, Z, A, B, G1, m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

CHEMICAL COMPOUNDS

The invention is directed to pyrido[4,3-d]pyrimidin-5(6H)-one derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1, R2, R3, and R4 are defined below. The compound