898550-57-7Relevant academic research and scientific papers
Exploiting the therapeutic potential of 8-β- d -glucopyranosylgenistein: Synthesis, antidiabetic activity, and molecular interaction with islet amyloid polypeptide and amyloid β-peptide (1-42)
Jesus, Ana R.,Dias, Catarina,Matos, Ana M.,De Almeida, Rodrigo F.M.,Viana, Ana S.,Marcelo, Filipa,Ribeiro, Rogério T.,Macedo, Maria P.,Airoldi, Cristina,Nicotra, Francesco,Martins, Alice,Cabrita, Eurico J.,Jiménez-Barbero, Jesús,Rauter, Amélia P.
, p. 9463 - 9472 (2015/02/02)
8-β-d-Glucopyranosylgenistein (1), the major component of Genista tenera, was synthesized and showed an extensive therapeutical impact in the treatment of STZ-induced diabetic rats, producing normalization of fasting hyperglycemia and amelioration of exce
Total synthesis of two isoflavone C-glycosides: genistein and orobol 8-C-β-d-glucopyranosides
Sato, Shingo,Hiroe, Kaoru,Kumazawa, Toshihiro,Jun-ichi, Onodera
, p. 1091 - 1095 (2007/10/03)
Genistein and orobol 8-C-β-d-glucopyranosides (1 and 3) were firstly synthesized in overall yields of 39% and 41% from 2,4-di-O-benzylphloroacetophenone (4), as follows: (1) the formation of the chalcone (6, 7) by aldol condensation of the benzyl-protecte
