898759-01-8

Usage

InChI:InChI=1/C12H13ClO3/c1-2-16-12(15)8-7-11(14)9-5-3-4-6-10(9)13/h3-6H,2,7-8H2,1H3

Upstream product

• 873-31-4 2-chlorophenylacetylene 
• 623-51-8 ethyl 2-sulfanylacetate 
• 84452-04-0 1-Chloro-2-(1-chloro-vinyl)-benzene 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 105-36-2 ethyl bromoacetate 
• 6414-69-3 ethyl 3-iodopropanoate 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 213964-17-1 4-(2-chloro-phenyl)-pent-4-enal 

Relevant academic research and scientific papers

Synthesis of Unsymmetrical 1,4-Dicarbonyl Compounds by Photocatalytic Oxidative Radical Additions

Herein we report a photocatalytic oxidative radical addition reaction for the synthesis of unsymmetrical 1,4-dicarbonyl compounds. This reaction utilizes a desulfurization process to generate electrophilic radicals, which add to α-halogenated alkenes and undergo further oxidation to deliver 1,4-dicarbonyl compounds. This mild and highly efficient method provides a valuable alternative to known strategies.

BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF

The invention provides novel compounds having the general formula (I): (I) wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

ortho-halogeno substituents effect in asymmetric cyclization of 4-aryl-4-pentenals using a rhodium catalyst

Asymmetric cyclization of 4-aryl-4-pentenals by using a cationic [Rh((R)-BINAP)]ClO4 afforded (3R)-3-substituted cyclopentanones; on the other hand, the cyclization of 4-pentenals bearing ortho-halogeno phenyl groups afforded the opposite (3S)-ones.