898769-06-7

Usage

InChI:InChI=1/C13H15BrO/c14-12-8-4-7-11(9-12)13(15)10-5-2-1-3-6-10/h4,7-10H,1-3,5-6H2

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 110-82-7 cyclohexane 
• 108-85-0 1-bromocyclohexane 
• 35306-75-3 3-bromobenzoic acid isopropylamide 
• 6815-55-0 1-(cyclohexylidenemethyl)pyrrolidine 

Downstream Products

• 1258203-15-4 C₁₄H₁₈BrN₃S 
• 1370549-36-2 tert-butyl 2-(3-(cyclohexanecarbonyl)phenyl)allylcarbamate 
• 1370549-46-4 (E)-N,N-bis(tert-butoxycarbonyl)-3-(3-(cyclohexanecarbonyl)phenyl)prop-2-en-1-amine 
• 1372805-99-6 C₁₅H₁₇BrN₂O₂ 
• 1049650-21-6 C₂₂H₂₄ClN₃O 
• 1049641-18-0 C₁₆H₂₀BrN₃O 
• 1372806-29-5 C₁₆H₁₉BrN₂OS 
• 1372806-14-8 C₁₆H₁₉BrN₂O₂ 

Relevant academic research and scientific papers

Cross-Coupling of Secondary Amides with Tertiary Amides: The Use of Tertiary Amides as Surrogates of Alkyl Carbanions for Ketone Synthesis

In recent years, exciting progress has been made in the field of direct transformation of amides, nevertheless, the condensation between two amides remains rare and restricted to homo-coupling reactions. Herein, we report the cross-coupling of secondary amides with tertiary amides, which provides a synthesis of ketones under mild conditions, and features the use of tertiary amides as surrogates of alkyl carbanions. The method relies on the coupling of enamines, generated from tertiary amides by catalytic partial reduction of tertiary amides with Vaska's catalyst, with nitrilium ions, formed in situ from secondary amides via activation with trifluoromethanesulfonic anhydride, and on the subsequent deformylation.

BIARYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

A ketone the synthetic method of the compound of (by machine translation)

The invention discloses a method for the synthesis of ketone compound, the aldehyde compound and cyclanes mixed or dissolved in organic solvent, in the microwave radiation and presence of radical initiator under the condition of the 140 [...] 180 °C reaction to obtain the target product ketone compound, in the synthesis method of the reaction equation: , Wherein R 1 is phenyl or substituted phenyl, substituted phenyl benzene ring substituted the base is the fluorine, chloro, bromo, methyl, methoxy, trifluoromethyl or hydroxy in one or more of, the position of the substituent on the benzene ring is ortho, meta or para position, as n the 1 [...] 4 integer between the, free-radical initiator is benzoyl peroxide, di-tert-butyl peroxide, or cumyl peroxide, organic solvent as the alkane or benzene. The invention discloses method for the synthesis of the raw material is cheap and easy to obtain, good atom economy, wide range of the application of substrates, and the like, is suitable for industrial production. (by machine translation)

Synthesis of Ketones through Microwave Irradiation Promoted Metal-Free Alkylation of Aldehydes by Activation of C(sp3)-H Bond

In this paper, a novel methodology for the synthesis of ketones via microwave irradiation promoted direct alkylation of aldehydes by activation of the inert C(sp3)-H bond has been developed. Notably, the reactions were accomplished under metal-free conditions and used commercially available aldehydes and cycloalkanes as substrates without prefunctionalization. By using this novel method, an alternative synthetic approach toward the key intermediates for the preparation of the pharmaceutically valuable oxaspiroketone derivatives was successfully established.