89889-51-0 Usage
Description
Biotin-LC-LC is a heterobiofunctional biotin PEG linker containing a carboxylic acid group. The extended spacer arm helps to minimize steric hindrance. With its uncharged, simple alkyl-chain spacer arm, this biotin compound is membrane-permeable and useful for intracellular labeling.
Chemical Properties
White Solid
Check Digit Verification of cas no
The CAS Registry Mumber 89889-51-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,8,8 and 9 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 89889-51:
(7*8)+(6*9)+(5*8)+(4*8)+(3*9)+(2*5)+(1*1)=220
220 % 10 = 0
So 89889-51-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H38N4O5S/c27-18(23-14-8-2-4-12-20(29)30)10-3-1-7-13-24-19(28)11-6-5-9-17-21-16(15-32-17)25-22(31)26-21/h16-17,21H,1-15H2,(H,23,27)(H,24,28)(H,29,30)(H2,25,26,31)/t16-,17-,21-/m0/s1
89889-51-0Relevant articles and documents
Synthesis and in?vitro anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin
Huang, Xiao-Lei,Chen, Jing-Lei,Li, Xian-Lun,Zhao, Lei,Cui, Ya-Dong,Liu, Jiang-Yun,Morris-Natschke, Susan L.,Masuo, Goto,Cheng, Yung-Yi,Lee, Kuo-Hsiung,Chen, Dao-Feng,Zhang, Jian
, p. 703 - 711 (2020/06/03)
Fourteen glaucocalyxin A biotinylated derivatives, one glaucocalyxin C biotinylated derivative, and two oridonin biotinylated derivatives were designed and synthesized. Their structures were confirmed from 1H NMR, 13C NMR and HRMS data. The derivatives were evaluated for cytotoxic activities against lung (A549), cervical cancer cell line HeLa derivative (KB), multidrug-resistant KB subline (KB-VIN), triple-negative breast (MDA-MB-231), and estrogen receptor-positive breast (MCF-7) cancer cell lines. (Figure presented.).
