89891-00-9Relevant academic research and scientific papers
Preparation method of heterocyclicpyrimidinedione compound
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Paragraph 0042; 0043; 0044, (2018/03/26)
The invention discloses a preparation method of a heterocyclicpyrimidinedione compound and relates to the technology of medicinal chemistry. The preparation method comprises the following steps: 1) mixing an o-amino formonitrile heterocyclic compound and a catalyst to form a mixture, wherein the catalyst is [HDBN][TFE]; 2) in a CO2 environment, heating the mixture and reacting; 3) when the temperature is reduced to room temperature, adjusting the pH value to neutrality, and extracting, separating and collecting the an organic phase; drying, filtering and then vaporizing; performing column chromatography separation to obtain the heterocyclicpyrimidinedione compound. The preparation method disclosed by the invention has the advantages of low cost, environmental friendliness, simple preparation process and wide application range of substrate.
Ionic liquid promoted synthesis of heterocycle-fused pyrimidine-2,4(1H,3H)-diones utilising CO2
Li, Chun,Lu, Xunhua,Yang, Yuanyong,Yang, Shenggang,Zhang, Lin
supporting information, p. 2463 - 2466 (2018/05/26)
An efficient ionic liquid system was developed for the preparation of various heterocycle-fused pyrimidine-2, 4(1H,3H)-diones in moderate to excellent yields (52–95%). It was found that [HDBN+][TFE?], a simple and easily prepared ionic liquid, could act as both the solvent and reaction promoter, and that the reactions could be efficiently carried out at atmospheric pressures of CO2.
Part 4. Fused Pyrimidines. Annelation Using Formamide to Synthesize 2,4-Disubstituted-PyrimidoPyrimidines
Delia, Thomas J.,Niedzinski, Jill
, p. 1421 - 1423 (2007/10/02)
A one-step synthesis of 2,4-disubstituted-pyrimidopyrimidines has been investigated.Cyclization of 6-amino-2,4-disubstituted-pyrimidines with formamide as solvent and reagent affords the title compounds in 50-70percent yield.Strongly electron-donating groups are required.Based on model compounds, a pathway for the cyclization is suggested.The method is an improvement on previous methods of synthesis, albeit a limited one.
