89892-39-7Relevant academic research and scientific papers
Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors
Hao, Guiyun,Li, Hao,Yang, Fei,Dong, Duoling,Li, Zezhong,Ding, Yingying,Pan, Wei,Wang, Enduo,Liu, Rujuan,Zhou, Huchen
, (2020/11/25)
Pneumonia caused by bacterium S. pneumoniae is a severe acute respiratory infectious disease with high morbidity and mortality, especially for children and immunity-compromised patients. The emergence of multidrug-resistant S. pneumoniae also presents a c
A NEW TYPE OF BENZOXABOROLE-BASED ANTI-PNEUMOCOCCAL COMPOUNDS TARGETING LEUCYL-TRNA SYNTHETASE
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Page/Page column 6, (2021/01/22)
Provided is benzoxaborole-based derivatives and their preparation and use. The structural general formula of the derivatives is (I). The derivatives are used for the preparation of a medicament for the prevention and treatment of Pneumonia. Compared with
Cross-coupling strategy for the synthesis of diazocines
Eleya, Nadi,Li, Shuo,Staubitz, Anne
supporting information, p. 1624 - 1627 (2020/03/13)
Ethylene bridged azobenzenes are novel, promising molecular switches that are thermodynamically more stable in the (Z) than in the (E) configuration, contrary to the linear azobenzene. However, their previous synthetic routes were often not general, and yields were poorly reproducible, and sometimes very low. Here we present a new synthetic strategy that is both versatile and reliable. Starting from widely available 2-bromobenzyl bromides, the designated molecules can be obtained in three simple steps.
GLUCOSE SENSITIVE INSULIN DERIVATIVES
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Page/Page column 160, (2020/10/20)
The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The invention
A general method for selective recognition of monosaccharides and oligosaccharides in water
Gunasekara, Roshan W.,Zhao, Yan
supporting information, p. 829 - 835 (2017/05/17)
Molecular recognition of carbohydrates plays vital roles in biology but has been difficult to achieve with synthetic receptors. Through covalent imprinting of carbohydrates in boroxole-functionalized cross-linked micelles, we prepared nanoparticle receptors for a wide variety of mono- and oligosaccharides. The boroxole functional monomer bound the sugar templates through cis-1,2-diol, cis-3,4-diol, and trans-4,6-diol. The protein-sized nanoparticles showed excellent selectivity for daldohexoses in water with submillimolar binding affinities and completely distinguished the three biologically important hexoses (glucose, mannose, and galactose). Glycosides with nonpolar aglycon showed stronger binding due to enhanced hydrophobic interactions. Oligosaccharides were distinguished on the basis of their monosaccharide building blocks, glycosidic linkages, chain length, as well as additional functional groups that could interact with the nanoparticles.
MICROBIOCIDAL BENZOXABOROLES
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Page/Page column 41, (2016/11/07)
Compounds of formula (I) are as defined in the claims, and their use in compositions and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.
Pesticidal compositions and processes related thereto
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Page/Page column 97; 98, (2016/01/09)
This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
2-ARYL SELENAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF
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Paragraph 0130; 0132, (2015/11/16)
Disclosed are a 2-aryl selenazole compound and a pharmaceutical composition thereof, where the 2-aryl selenazole compound is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The 2-aryl selenazole compound has the activi
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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Page/Page column, (2014/06/25)
This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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Page/Page column 96; 97, (2014/07/08)
This document discloses molecules having the following formula ("Formula One"): and processes associated therewith.
