89899-44-5

Usage

Preparation

Preparation by bromination of p-hydroxybenzophenone with bromine, in acetic acid or in chloroform.

Upstream product

• 116413-49-1 (3-bromo-4-methoxyphenyl)-phenylmethanone 
• 1137-42-4 4-Hydroxybenzophenone 
• 95-56-7 2-hydroxybromobenzene 
• 98-88-4 benzoyl chloride 
• 578-57-4 2-bromoanisole 
• 155291-43-3 4-benzyl-2-bromophenol 
• 91805-61-7 2-bromophenyl benzoate 
• 611-94-9 4-Methoxybenzophenone 
• 615-58-7 2,4-dibromophenol 
• 98-07-7 Benzotrichlorid 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 833-39-6 4-hydroxy-benzhydrol 

Relevant academic research and scientific papers

Synthesis, characterization, docking study and antimicrobial activity of 2-(4-benzoylphenoxy)-1-[2-(1-methyl-1H-indol-3-yl)methyl)-1H-benzo[d]imidazol-1-yl] ethanone derivatives

The occurrence of drug-resistant bacterial infections impulses the development of new antibacterial agents that own a mechanism of action different from traditional antibiotics. From the earlier days, benzophenone, indole and benzimidazole moieties alone

Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

We synthesized and evaluated a series of compounds for their allosteric modulation at the Kv11.1 (hERG) channel. Most compounds were negative allosteric modulators of [3H]dofetilide binding to the channel, in particular 7f, 7h-j and 7p. Compounds 7f and 7p were the most potent negative allosteric modulators amongst all ligands, significantly increasing the dissociation rate of dofetilide in the radioligand kinetic binding assay, while remarkably reducing the affinities of dofetilide and astemizole in a competitive displacement assay. Additionally, both 7f and 7p displayed peculiar displacement characteristics with Hill coefficients significantly distinct from unity as shown by e.g., dofetilide, further indicative of their allosteric effects on dofetilide binding. Our findings in this investigation yielded several promising negative allosteric modulators for future functional and clinical research with respect to their antiarrhythmic propensities, either alone or in combination with known Kv11.1 blockers.

An eco-friendly Co(OAc)2-catalyzed aerobic oxidation of 4-benzylphenols into 4-hydroxybenzophenones

An undecorated Co(OAc)2-catalyzed aerobic oxidation system has been reported that enables direct transformation of 4-benzylphenols into the corresponding 4-hydroxybenzophenones. The procedure is especially suitable for electron-withdrawing group-containing substrates, which are commonly inefficient to conduct this category of oxidation. Based on well-defined p-benzoquinone methides and the confirmed ethereal intermediate, a plausible mechanism was depicted.

Synthesis and evaluation of novel benzophenone-thiazole derivatives as potent VEGF-A inhibitors

A series of 2-(4-benzoyl-phenoxy)-N-(4-phenyl-thiazol-2-yl)-Acetamides (10a-n) were synthesized by multistep reaction sequence and all the compounds were well characterized for structural elucidation. The in vitro cytotoxicity of compounds 10a-n was evaluated against EAC and DLA cell lines using trypan blue dye exclusion method. Further MTT assay and LDH release assay, followed by in vivo studies on murine model were also evaluated. The compound 10h with a methyl and fluoro groups at benzophenone moiety and methoxy group at phenyl ring was in a leading position to exhibit the promising antiproliferative effect through translational VEGF-A inhibition.

Tetrameric DABCO-bromine: An efficient and versatile reagent for bromination of various organic compounds

Tetrameric DABCO-bromine is a powerful brominating agent but shows reasonable selectivity with certain substrates. The selective bromination for activated aromatic compounds and alkenes is reported. Synthesis of α-bromo ketones and nitriles has also been achieved by using this reagent and the results are also reported. All products reported were obtained in good to excellent yields.

Regioselective and high-yielding bromination of aromatic compounds using hexamethylenetetramine-bromine

A regioselective and highly efficient method for bromination of aromatic compounds in the presence of a stoichiometric amount of hexamethylenetetramine- bromine (HMTAB) as an efficient reagent in dichloromethane is reported. The selectivity depends on the temperature and nature of the substituent on the substrate. The reactivity of this reagent was increased by supporting it to silica gel for bromination of less activated compounds.

Alkaline Condensation of Benzotrichloride with Bromophenols

The reaction of benzotrichloride with 4-alkylphenols is of potential industrial importance to sythesize 2-hydroxy-5-alkylbenzophenones which are industrial oxime extractants used for extraction of copper and other metals.The attempts to obtain 2-hydroxychlorobenzophenone derivatives from 4-chlorophenol and 2,4-dichlorophenol, respectively and benzotrichloride yields besides 2-hydroxychlorobenzophenone, hydroxyketones having fewer atoms of chlorine in the aromatic ring as well as hydroxychlorobenzophenones resulting from the migration of chlorine from the para to the ortho position.In the present paper the reaction between benzotrichloride and bromophenols is studied.