89900-94-7

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 3'-methylbiphenyl-4-carboxylate is used as an intermediate in the synthesis of various pharmaceuticals for its unique chemical structure and properties. It contributes to the development of new drugs and medicines.
Used in Organic Synthesis:
In the field of organic synthesis, methyl 3'-methylbiphenyl-4-carboxylate serves as a key building block for the creation of complex organic molecules. Its versatile structure allows for further functionalization and modification, enabling the synthesis of a wide range of organic compounds.
It is crucial to handle methyl 3'-methylbiphenyl-4-carboxylate with care and follow safety guidelines to minimize potential health and environmental hazards associated with its use.

Upstream product

• 17933-03-8 m-tolylboronic acid 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 619-44-3 methyl 4-iodobenzoate 
• 108-88-3 toluene 
• 1571-08-0 methyl 4-formylbenzoate 
• 67-56-1 methanol 

Downstream Products

• 5728-33-6 3'‐methyl‐(1,1'‐biphenyl)‐4‐carboxylic acid 

Relevant academic research and scientific papers

Molecular Design of Donor-Acceptor-Type Organic Photocatalysts for Metal-free Aromatic C?C Bond Formations under Visible Light

Metal-free and photocatalytic radical-mediated aromatic C?C bond formations offer a promising alternative pathway to the conventional transition metal-catalyzed cross-coupling reactions. However, the formation of aryl radicals from common precursors such as aryl halides is highly challenging due to their extremely high reductive potential. Here, we report a structural design strategy of donor-acceptor-type organic photocatalysts for visible light-driven C?C bond formations through the reductive dehalogenation of aryl halides. The reduction potential of the photocatalysts could be systematically aligned to be ?2.04 V vs. SCE via a simple heteroatom engineering of the donor-acceptor moieties. The high reductive potential of the molecular photocatalyst could reduce various aryl halides into aryl radicals to form the C?C bond with heteroarenes. The designability of the molecular photocatalyst further allowed the synthesis of a high LUMO (lowest unoccupied molecular orbital) polymer photocatalyst by a self-initiated free radical polymerization without compromising its LUMO level. (Figure presented.).

Metal-free oxidative decarbonylative coupling of aromatic aldehydes with arenes: Direct access to biaryls

A metal-free oxidative decarbonylative coupling of aromatic aldehydes with electron-rich or electron-deficient arenes to produce biaryl compounds was developed. This novel coupling was proposed to proceed via a non-chain radical homolytic aromatic substitution (HAS) type mechanism, based on the substrate scope, ortho-regioselectivity, radical trapping experiments and DFT calculation studies. With the ready availability of aromatic aldehydes and arenes, metal-free conditions should make this coupling attractive for the biaryl synthesis.

Metal-free iodination of arylboronic acids and the synthesis of biaryl derivatives

A simple, general and efficient method is developed for the metal-free iodination of arylboronic acids. The protocol uses very cheap molecular iodine as the halide source and potassium carbonate as the base. The method is highly tolerant of various functional groups present in the substrates. Importantly, the iodination strategy can also be applied very effectively in the one-pot, two-step synthesis of biaryl derivatives. Georg Thieme Verlag Stuttgart New York.

Use of functionalized onium salts as a soluble support for organic synthesis

The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A1+, X1?, wherein A1+ represents a cation and X1? represents an anion.