89900-96-9

Upstream product

• 67-56-1 methanol 
• 3808-93-3 2'-chloro[1,1'-biphenyl]-4-carboxylic acid 
• 6018-41-3 methyl coumalate 
• 2039-87-4 2-chlorostyrene 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 108-90-7 chlorobenzene 
• 1571-08-0 methyl 4-formylbenzoate 

Downstream Products

• 109524-03-0 2'-chlorobiphenyl-4-ylmethanol 
• 39802-78-3 4-(2-chloro-phenyl)-benzaldehyde 

Relevant academic research and scientific papers

A self-assembled bisoxazoline/Pd composite microsphere as an excellent catalyst for Suzuki-Miyaura coupling reactions

A palladium complex based on a novel oxazoline, a solid microsphere catalyst, was successfully prepared. The structure and composition of the solid catalyst were characterized by SEM, 1H NMR, TGA and FT-IR. This catalyst exhibits high catalytic activity for Suzuki-Miyaura cross-coupling reactions of various aryl halides and arylboronic acids in aqueous media. Moreover, the catalyst shows outstanding stability and reusability, and it can be recovered simply and effectively and reused eight times without any activity decrease.

An imidazolium ionic compound-supported palladium complex as an efficient catalyst for Suzuki-Miyaura reactions in aqueous media

A water soluble and efficient ionic compound-supported palladium complex was prepared. The structure and composition of the complex was characterized by FT-IR, NMR, ICP-OES and mass spectrometry. The complex exhibits high catalytic activity for Suzuki-Miyaura reactions in aqueous media. Moreover, the catalyst shows outstanding stability and reusability, and it can be recovered simply and effectively and reused six times without much activity decrease.

Metal-free oxidative decarbonylative coupling of aromatic aldehydes with arenes: Direct access to biaryls

A metal-free oxidative decarbonylative coupling of aromatic aldehydes with electron-rich or electron-deficient arenes to produce biaryl compounds was developed. This novel coupling was proposed to proceed via a non-chain radical homolytic aromatic substitution (HAS) type mechanism, based on the substrate scope, ortho-regioselectivity, radical trapping experiments and DFT calculation studies. With the ready availability of aromatic aldehydes and arenes, metal-free conditions should make this coupling attractive for the biaryl synthesis.

INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS

The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.

MUSCARINIC AGONISTS

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

MUSCARINIC AGONISTS

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

A convenient synthesis of methyl 4-substituted benzoates via Diels-Alder reaction in the presence of palladium on activated carbon

The thermal reaction of methyl 2-oxo-2H-pyran-5-carboxylates with substituted styrenes in the presence of 10% palladium on activated carbon afforded directly the corresponding methyl 4-biphenylcarboxylates in good yields. By the similar procedure, methyl 4-heteroaryl- and 4-alkyl-substituted benzoates were obtained from heteroaromatic olefines and alkenes, respectively.

Comparison of the Properties of Liquid Crystals Derived from Certain Lateral Halogeno-substituted Azomethines

Twenty-eight 4-n-alkoxy-N-(2- and 2'-halogenobiphenyl-4-ylmethylene)anilines comprising 4,8,8,4, and 4 members derived , respectively, from 2-fluoro-, 2'-fluoro-, 2'-chloro-, 2'-bromo-, and 2'-iodo-biphenyl-4-carbaldehyde, together with six 4-p-n-alkoxy-2'-fluorobenzylideneaminobiphenyls have been prepared.The liquid crystal behaviour of these compounds has been compared with analogous azomethines with reversed CH=N linkage, previously reported.

The Effects of Substituents on the Rate of Saponification of Biphenyl-4-carboxylates

Second-order rate constants have been measured for the saponification of methyl 2'-, 3'-, and 4'-substituted biphenyl-4-carboxylates at several temperatures in 85percent (w/w) methanol-water and activation parameters have been calculated.The Hammett equation applies very well to the saponification of 3'- and 4'-substituted biphenyl-4-carboxylates with ?-constants evaluated by the FMMF method.The effect of 2'-substituents is understandable in terms of ?-electron steric effects.