89947-88-6

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 130999-19-8 N⁶-dimethoxytrityl-2'-deoxyadenosine 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 
• 89947-86-4 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine 
• 958-09-8 2'-deoxy-D-adenosine 
• 17331-22-5 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine 
• 76223-08-0 N⁶,O^3'_,O5'-tris-trimethylsilanyl-2'-deoxy-adenosine 
• 89947-87-5 3'-O-t-butyldimethylsilyl-N,5'-O-bis(di-p-methoxytrityl) deoxyadenosine 

Downstream Products

• 108220-80-0 C₅₅H₅₁Cl₃N₅O₁₁P*C₆H₁₅N 
• 92127-73-6 (R)-Thiophosphoric acid O-[(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl] ester O'-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 103128-33-2 C₆₉H₆₆N₇O₁₃PS₃ 
• 103128-33-2 C₆₉H₆₆N₇O₁₃PS₃ 
• 103093-86-3 C₆₉H₆₆N₇O₁₃PS₂ 
• 89947-92-2 Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine 
• 103128-32-1 C₇₆H₆₉ClN₇O₁₄PS₂ 
• 108220-81-1 C₇₂H₆₇Cl₃N₇O₁₅PS₂ 

Relevant academic research and scientific papers

Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides

Phosphorothioate oligonucleotides manufactured by standard phosphoramidite techniques using 2′-deoxyadenosine- or 2′-O-(2-methoxyethyl)-5- methylcytosine-loaded solid supports contain branched impurities consisting of two chains linked through the exocycl

Functionalization of solid supports with N-unprotected deoxyribonucleosides

N-Unprotected deoxyribonucleotides were loaded to solid supports via a succinyl or an oxalyl linker. These solid supports were successfully used for oligonucleotide synthesis by the H-phosphonate method without N-protecting groups.

STEREOSPECIFIC SYNTHESIS OF DINUCLEOSIDE MONOPHOSPHATE ARYL ESTERS BY USING NEW CONDENSING REAGENTS

New condensing reagents, arenesulfonyl 5-(pyridin-2-yl)tetrazoles have been synthesized and used for stereospecific synthesis of dinucleoside monophosphate aryl esters.