89976-98-7Relevant academic research and scientific papers
An efficient process for the synthesis of gem-dinitro compounds under high steric hindrance by nitrosation and oxidation of secondary nitroalkanes
Zhang, Jian,Hou, Tianjiao,Ling, Yifei,Zhang, Lin,Luo, Jun
, p. 2880 - 2883 (2018)
A new nitrosation and oxidation process to synthesize gem-dinitro compounds was accomplished by using nitryl chloride as nitrosation reagent and ozone as oxidizing agent. The main features of the present protocol include the compatibility to substances with high steric hindrance, high yields and mild reaction conditions. A plausible mechanism involving the formation of an intermediate of gem-nitrosonitro compound by means of single electron transfer was also proposed.
Gem-Dinitroalkyl Benzenes: A Novel Class of IOP-Lowering Agents for the Treatment of Ocular Hypertension
Blangetti, Marco,Rolando, Barbara,Marini, Elisabetta,Chegaev, Konstantin,Guglielmo, Stefano,Lazzarato, Loretta,Lucarini, Laura,Masini, Emanuela,Fruttero, Roberta
supporting information, p. 1054 - 1059 (2017/10/18)
Primary open angle glaucoma is the second most common cause of blindness worldwide. Nitric oxide has recently received particular attention as a potential antiglaucoma agent. In this work, gem-dinitroalkyl benzenes are evaluated for their capability to ac
1,1-Dinitroethyl substituted furoxans: A new class of vasodilators and inhibitors of platelet aggregation
Gasco,Di Stilo,Sorba,Gasco,Ferioli,Folco,Civelli,Caruso
, p. 433 - 438 (2007/10/02)
The synthesis and structural characterization of a series of 1,1-dinitroethyl substituted furoxans are described. Their vasodilatory properties, evaluated on isolated rings of rabbit thoracic aorta precontracted with noradrenaline, as well as their abilit
