89978-12-1

Upstream product

• 151-50-8 potassium cyanide 
• 104-88-1 4-chlorobenzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 13086-93-6 (acetyloxy)(4-chlorophenyl)methyl acetate 

Downstream Products

• 90272-14-3 (4-chloro-phenyl)-thiocyanato-acetonitrile 
• 92545-82-9 N-[2-bromo-5-(4-chloro-phenyl)-thiazol-4-yl]-acetamide 
• 1403873-41-5 2,3-bis(4-chlorophenyl)-1-methylindolizine 
• 1403873-22-2 1-[(4-chlorophenyl)(cyano)methyl]pyridinium chloride 

Relevant academic research and scientific papers

The chemistry of acylals. 3. Cyanohydrin esters from acylals with cyanide reagents

(equation presented) When treated with KCN in DMSO at room temperature, acylals from aliphatic aldehydes gave the corresponding cyanohydrin esters in good to excellent yields. Acylals from aromatic aldehydes were less reactive and gave several byproducts in addition to fair yields of cyanohydrin under the same conditions. Trimethylsilyl cyanide mixed with titanium(IV) chloride afforded cyanohydrin esters in good to excellent yields from both aliphatic and aromatic aldehydes.

ONE-POT SYNTHESIS OF α-CHLORONITRILES FROM ARYLCARBONYL COMPOUNDS

α-Chloronitriles are prepared by the reaction of arylcarbonyl compounds and trimethylsilyl cyanide with a stoichiometric amount of titanium tetrachloride in good yields.