89983-14-2Relevant academic research and scientific papers
Conceptual Basis of the Selective Activation of Bis(dialkylamino)methoxyphosphines by Weak Acids and Its Application toward the Preparation of Deoxynucleoside Phosphoramidites in Situ
Moore, Michael F.,Beaucage, Serge L.
, p. 2019 - 2025 (1985)
The concept behind the selective activation of bis(dialkylamino)methoxyphosphines is experimentally examined and subsequently used in the preparation of deoxynucleoside phosphoramidites in situ.These intermediates are most efficiently prepared from the reaction of suitably protected deoxynucleosides with dipyrrolidinomethoxyphosphine in the presence of 4,5-dichloroimidazole using 1-methyl-2-pyrrolidinone as solvent.The purity and efficiency of these monomers are evaluated during the solid-phase synthesis of a 22-unit oligomer.
A SIMPLE AND EFFICIENT PREPARATION OF DEOXYNUCLEOSIDE PHOSPHORAMIDITES IN SITU
Beaucage, Serge L.
, p. 375 - 378 (2007/10/02)
A highly selective activation of bis-(pyrrolidino) methoxyphosphine by 4,5-dichloro-imidazole has been developed and successfully used in the preparation of deoxynucleoside phosphoramidites.
