900159-01-5

Upstream product

• 853400-83-6 (S)-2-[((S)-5,5-Dimethyl-pyrrolidine-2-carbonyl)-amino]-pentanedioic acid dibenzyl ester 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 943318-67-0 (S)-1-(tert-butoxycarbonyl)-5,5-dimethylpyrrolidine-2-carboxylic acid 
• 146954-59-8 5,5-dimethylpyrrolidine-2-carboxylic acid 
• 2768-50-5 dibenzyl L-glutamate 
• 900159-00-4 2-[(1-tert-butoxycarbonyl-5,5-dimethyl-pyrrolidine-2-carbonyl)-amino]-pentanedioic acid dibenzyl ester 
• 900158-99-8 1-(tert-Butoxycarbonyl)-5,5-dimethylpyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity

The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not dir

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): Synthesis and structure-activity relationships

A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role