9002-96-4 Usage
Chemical Properties
Vitamin E polyethylene glycol succinate is a synthetic product. It is
available as a white to light-brown, waxy solid and is practically
tasteless. Chemically, it is a mixture composed principally of
monoesterified polyethylene glycol 1000, the diesterified polyethylene
glycol 1000, free polyethylene glycol 1000, and free tocopherol.
Uses
Different sources of media describe the Uses of 9002-96-4 differently. You can refer to the following data:
1. Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems.
2. tocophersolan is an anti-oxidant, this is a water-soluble form of vitamin e.
3. Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21
Production Methods
Vitamin E polyethylene glycol succinate is prepared by esterification
of the acid group of crystalline D-a-tocopheryl acid succinate by
polyethylene glycol 1000.
Pharmaceutical Applications
Vitamin E polyethylene glycol succinate is an esterified vitamin E
(tocopherol) derivative primarily used as a solubilizer or emulsifying
agent because of its surfactant properties. Structurally, it is
amphipathic and hydrophilic, unlike the tocopherols, and therefore
it is a water-soluble derivative that can be used in pharmaceutical
formulations such as capsules, tablets, hot-melt extrusion,
microemulsions, topical products, and parenterals. One of
the most important applications is its use as a vehicle for lipid-based
drug delivery formulations. It can also be used as a source of
vitamin E.
Vitamin E polyethylene glycol succinate has been characterized
with respect to its mechanism of action and studied as a Pglycoprotein
inhibitor.
Biochem/physiol Actions
D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) also known as vitamin E TPGS, is a therapeutic agent for vitamin E deficiency in children, administered during chronic childhood cholestasis. TPGS exerts anti-tumor activity in MCF-7 and breast cancer cells by downregulating anti-apoptotic proteins. TPGS finds its application as an emulsifier in the preparation of poly(lactic-co-glycolic acid) (PLGA) particles for DNA labelling, produces particles of uniform size, high encapsulation efficiency, increases hydrophilicity and prevents aggregation of particles.
Safety
Vitamin E polyethylene glycol succinate has been used at levels of
280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An
additional assessment of the safety of vitamin E polyethylene glycol
succinate has been published, which includes a report showing
no-observed-adverse-effect-level (NOAEL) in rats of
1000 mg/kg/day.
storage
Vitamin E polyethylene glycol succinate is stable at ambient room
temperature for up to 4 years. It reacts with alkalis and acids.
Aqueous solutions of vitamin E polyethylene glycol succinate are
stable over a pH range of 4.5–7.5 and can be further stabilized with
propylene glycol.
Incompatibilities
Vitamin E polyethylene glycol succinate is incompatible with strong
acids and strong alkalis.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database
(ophthalmic solution or drops; oral capsules, solution, tablet;
topical solution or drops). Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 9002-96-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 2 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 9002-96:
(6*9)+(5*0)+(4*0)+(3*2)+(2*9)+(1*6)=84
84 % 10 = 4
So 9002-96-4 is a valid CAS Registry Number.
InChI:InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
9002-96-4Relevant articles and documents
Tocopherol-modified therapeutic drug compounds
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Page column 14, (2010/02/11)
Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.
