9004-77-7Relevant academic research and scientific papers
Preparation method of alkyl diglycol (by machine translation)
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Paragraph 0031-0044, (2020/06/09)
The invention relates to a preparation method of alkyl diglycol with NRE (narrow distribution ethoxylate Narrow Range Ethoxylate) effect while increasing the reaction speed in the presence of a novel aluminum-based catalyst containing alkali metal or alkaline earth metal. (by machine translation)
Fenton-Inspired C-H Functionalization: Peroxide-Directed C-H Thioetherification
Groendyke, Brian J.,Modak, Atanu,Cook, Silas P.
, p. 13073 - 13091 (2019/10/10)
Substoichiometric iron mediates the thioetherification of unactivated aliphatic C-H bonds directed by resident silylperoxides. Upon exposure to a catalytic amount of iron(II) triflate, TIPS-protected peroxides bearing primary, secondary, and tertiary C-H sites undergo chemoselective thioetherification of remote C-H bonds with diaryl disulfides. The reaction demonstrates a broad substrate scope and functional group tolerance without the use of any noble metal additives. Mechanistic experiments suggest that the reaction proceeds through 1,5-H atom abstraction by a hydroxyl radical generated with iron.
OPEN-FLASK HYDROBORATION AND THE USE THEREOF
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Paragraph 0046; 0058; 0059, (2018/03/25)
The present disclosure generally relates to a process for hydroboration of an alkene or alkyne using ammonia borane (AB). In particular, the present invention relates to hydroboration of an alkene or alkyne in the presence of air or moisture, and a clean process for facile preparation of an alcohol by oxidizing the organoborane so formed with hydrogen peroxide. The products, including aminodialkylboranes, ammonia trialkylborane complexes, as well as various alcohols so prepared, are within the scope of this disclosure.
Green synthesis method for preparing alcohol ether by using olefin in one step
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Paragraph 0018, (2018/01/12)
The invention belongs to the field of organic chemical industry, and provides a green synthesis method for preparing alcohol ether by using olefin in one step. The green synthesis method is characterized in that a jet type reactor is used for continuously jetting alcohol, hydrogen peroxide and a cyclization-alcoholysis catalyst into a pressured reaction kettle filled with olefin gas, so that continuous epoxidation and alcoholysis reaction is carried out; after being separated by a ceramic membrane, reaction liquid enters to an olefin and alcohol removal tower; after olefin and alcohol are removed, the reaction liquid directly and continuously enters to a rectifying tower, and the alcohol ether product is obtained by rectifying; the effective utilization rate of the hydrogen peroxide is more than or equal to 98%, the alcohol ether selectively is greater than or equal to 99%, and the product purity is higher than or equal to 99.5%. The green synthesis method can be used for preparing the alcohol ether in one step and is suitable for industrial large-scale production.
Preparation method of ethylene glycol monobutyl ether
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Paragraph 0019; 0021, (2017/07/18)
The invention relates to the field of chemistry and chemical engineering and particularly discloses a preparation method of ethylene glycol monobutyl ether. The preparation method of the ethylene glycol monobutyl ether is characterized in that ethylene oxide and n-butyl alcohol are prepared into a raw material mixed solution, and cold storage is performed for usage; high-silicon-content alloy or an all-silicon molecular sieve and porous silicon dioxide are put in a muffle furnace to perform high-temperature roasting, and a roasting catalyst is put in a dryer for usage after being numbered; the raw material solution and the roasting catalyst are put in a reaction kettle for reaction, and a product is obtained. The high-silicon-content alloy or the all-silicon molecular sieve and the porous silicon dioxide used by the method is low in procurement cost, the treating process is simple, a production process is greatly simplified, the production cost is reduced, the catalyst or ethylene glycol butyl ether is high in selectivity, and the preparation method has very high stability.
INHIBITORS OF HEPATITIS C VIRUS POLYMERASE
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Paragraph 331; 332, (2016/10/11)
The present invention provides, among other things, compounds represented by the general Formula I: (I) and pharmaceutically acceptable salts thereof, wherein L and A (and further substituents) are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
Method for preparing butoxy methoxy methane
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Paragraph 0018; 0019, (2017/03/28)
The invention provides a method for preparing butoxy methoxy methane and relates to a method for preparing methane. The method includes a synthesis path of ethylene glycol monobutyl ether, the path includes three steps that 1, methylal and butyl alcohol synthesize the butoxy methoxy methane; 2, directional carbonylation of the butoxy methoxy methane is conducted, and butoxy methyl acetate is generated; 3, hydrogenation is conducted on the butoxy methyl acetate to generate the ethylene glycol monobutyl ether and methane; dimethoxymethane and n-butyl alcohol serve as raw materials, under the temperature and pressure, resin serves as a catalyst, the butoxy methoxy methane is prepared. The brand new synthesis path of the ethylene glycol monobutyl ether and the preparation method of the butoxy methoxy methane are developed; the required raw materials are cheap and easy to obtain, the whole procedure is simple in operation, a product is singular and high in selectivity, good application prospect is achieved, and the butoxy methoxy methane is suitable for industrial production.
A non-dissociative open-flask hydroboration with ammonia borane: Ready synthesis of ammonia-trialkylboranes and aminodialkylboranes
Ramachandran, P. Veeraraghavan,Drolet, Michael P.,Kulkarni, Ameya S.
supporting information, p. 11897 - 11900 (2016/10/09)
Under open-flask conditions, ammonia borane hydroborates olefins in refluxing tetrahydrofuran. Unlike conventional hydroboration, the Lewis base (ammonia) is not dissociated from the boron center. Terminal alkenes selectively provide ammonia-trialkylborane complexes. On the other hand, internal alkenes afford aminodialkylboranes via a metal-free hydroboration-dehydrogenation sequence. Alkaline hydrogen peroxide oxidation of the products provides the corresponding alcohols in high yields.
Synthesis of alkyl hydroperoxides via alkylation of gem -dihydroperoxides
Kyasa, Shivakumar,Puffer, Benjamin W.,Dussault, Patrick H.
, p. 3452 - 3456 (2013/06/26)
2-Fold alkylation of 1,1-dihydroperoxides, followed by hydrolysis of the resulting bisperoxyacetals, provides a convenient method for synthesis of primary and secondary alkyl hydroperoxides.
PRODUCTION OF HYDROXY ETHER HYDROCARBONS BY VAPOR PHASE HYDROGENOLYSIS OF CYCLIC ACETALS AND KETALS
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Page/Page column 11, (2013/02/28)
A vapor phase hydrogenolysis reaction to convert cyclic acetal compounds and/or cyclic ketal compounds in the presence of hydrogen to their corresponding hydroxy ether hydrocarbon reaction products using a supported noble metal catalyst. The hydrogenolysis reaction can be carried out in the vapor phase and in the absence of a polyhydroxyl hydrocarbon co-solvent.
