900537-08-8

Upstream product

• 900537-07-7 di(1R,2S,5R)-menthyl methylphosphonate 
• 79-04-9 chloroacetyl chloride 
• 2216-51-5 (-)-menthol 

Downstream Products

• 900537-05-5 bis[(1R,2S,5R)-menthyl] ((S)-3-chloro-2-hydroxypropyl)phosphonate 
• 945652-59-5 di(1R,2S,5R)-menthyl [(R)-2-hydroxy-3-chloropropyl]phosphonate 
• 945652-64-2 di(1R,2S,5R)-menthyl (2R)-2-hydroxy-3-azidopropylphosphonate 
• 945652-62-0 bis[(1R,2S,5R)-menthyl] [(2R)-3-(dibenzylamino)-2-hydroxypropyl]phosphonate 
• 945652-61-9 bis[(1R,2S,5R)-menthyl] (2R)-(oxiran-2-yl)-methylphosphonate 

Relevant academic research and scientific papers

Di(1R,2S,5R)-menthyl 2-hydroxy-3-chloropropylphosphonate as a useful chiral synthon for the preparation of enantiomerically pure phosphonic acids

Stereochemically pure di(1R,2S,5R)-menthyl (S)- and (R)-2-hydroxy-3- chloropropylphosphonates were synthesized by reaction of di(1R,2S,5R)-menthyl ketophosphonate with chiral complexes prepared from sodium borohydride and (R,R)-(+)-tartaric acid or with (

Efficient method for the asymmetric reduction of α- and β-ketophosphonates

An efficient and versatile method for the asymmetric reduction of α- and β-ketophosphonates using chiral reactant derived from sodium borohydride and l-(+)- or d-(-)-tartaric acid is developed. The methodology was used for the preparation of a number of biologically interesting enantiomerically pure products: including 2,3-epoxypropylphosphonate 11, 2-hydroxy-3-aminopropylphosphonic acid 14 (phospho-GABOB), phospho-carnitine 19, and others in multigram scale.

New method for the asymmetric hydroboration of ketophosphonates and the synthesis of phospho-carnitine

The reduction of α- or β-ketophosphonates with a chiral reactant 1, prepared from sodium borohydride and (R)- or (S)-tartaric acids, led to the formation of both (S)- and (R)-α- or β-hydroxyphosphonates in high yields. The stereoselectivity of the reactio