9007-90-3 Usage
Description
Gliadin is a strongly hydrophobic glycoprotein that is a component of gluten, the protein found in wheat, rye, and other grains. It has very poor solubility and is composed of 18 amino acids, with 40% being glutamic acid. Gliadins can be further subdivided into α-gliadins, γ-gliadins, and ω-gliadins based on their order of mobility on electrophoresis at low pH.
Uses
Used in Pharmaceutical Industry:
Gliadin is used in the chemical synthesis of spinal anesthetics and as a component in pharmaceutical preparations.
Used in Medical Research:
Gliadin from wheat has been used in peptic tryptic digestion to study the in vitro gliadin challenge on biopsies from celiac disease (CD) patients on a gluten-free diet (GFD).
Used in Diagnostic Assays:
Gliadin is used to prepare gliadin for antigliadin antibody assays, which are used to diagnose celiac disease and other gluten-related disorders.
Used in Analytical Techniques:
Gliadin serves as a standard for the quantification of gliadin levels to the picogram level by flow cytometry, allowing for accurate measurement and detection of gliadin in various samples.
Biochem/physiol Actions
The gliadins comprise a family of glutamine- and proline-rich monomeric proteins that account for 40-50% of the total protein content of wheat kernels. The alcohol-soluble gliadins aggregate with the alcohol-insoluble glutenins to form gluten, which is responsible for the structure and properties of wheat dough. The gliadins are also involved in the pathogenesis of celiac disease. an autoimmune disease in which human leukocyte antigens DQ2 and DQ8 present gliaden peptides to a subset of T cells inducing the release of proinflammatory cytokines that, in turn, induce degradation of the intestinal mucosal matrix and cell death. B cells are also stimulated to produce gluten-specific and transglutaminase 2 (TG2)-specific antibodies, the latter may result from the presentation of gliadin peptides covalently bound to TG2.
Check Digit Verification of cas no
The CAS Registry Mumber 9007-90-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 9007-90:
(6*9)+(5*0)+(4*0)+(3*7)+(2*9)+(1*0)=93
93 % 10 = 3
So 9007-90-3 is a valid CAS Registry Number.
