90072-35-8

Upstream product

• 67-56-1 methanol 
• 4378-10-3 O-benzyl-L-threonine 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 137719-70-1 Boc-L-Thr(Bn)-OMe 
• 117872-75-0 (2S,3R)-Fmoc-O-benzyl-threonine 
• 339048-94-1 (2S,3R)-N-Fmoc-O-benzyl-threonine methyl ester 

Downstream Products

• 936710-33-7 C₁₅H₁₉O₄N 
• 1225187-83-6 C₂₇H₃₄N₂O₆ 
• 1272318-12-3 (2S,3R)-methyl 3-(benzyloxy)-2-((1S,2R,4S,5R)-4-(tert-butoxycarbonylamino)-6-oxabicyclo [3.1.0] hexane-2-carboxamido)butanoate 
• 887246-25-5 C₂₃H₂₄N₂O₄ 
• 1036275-52-1 N-[(1S,2R)-1-methoxycarbonyl-2-benzyloxypropyl]-(R)-2-cyano-2-fluoro-p-tolylacetamide 
• 1036275-11-2 N-[(1S,2R)-1-methoxycarbonyl-2-benzyloxypropyl]-(+/-)-2-cyano-2-fluoro-p-tolylacetamide 

Relevant academic research and scientific papers

Chemoselective opening of Vince lactam epoxide with nitrogen nucleophiles

Here is reported the chemoselective opening of the amide bond on a Vince lactam derivative with amines, without the cleavage of the epoxide-moiety, getting five new epoxides. Also reported is the rearrangement of the epoxides into the respective five new

A class of novel Schiff's bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis

To discover analgesics for treating chronic pain 17 novel Schiff's bases, N,N′-(Z-allylidene-1,3-diyl)bisamino acid methyl esters were prepared from 1,1,3,3,-tetramethoxypropane and amino acid methyl esters. On tail-flick mouse model 20 μmol/kg of these Schiff's bases were orally administered, the analgesic action started 30 min after administration, reached the maximum 120 min after administration, and at 180 min this action was still observed. On a xylene-induced ear edema mouse model 20 μmol/kg of these Schiff's bases exhibited desirable anti-inflammation. Thus the present Schiff's bases are able to treat chronic pain from inflammation. The effect of the side chains of the amino acid residues of these Schiff's bases on the analgesic activity was explained with 3D QSAR.

A microwave enhanced cross-metathesis approach to peptidomimetics

Functionalization of amino acid C- and N-termini with appropriate olefinic moieties allows for the generation of a peptidomimetic via a stereoselective cross-metathesis. This journal is The Royal Society of Chemistry.