90085-61-3

Basic information

• Product Name: 2-BroMo-2-cyclohexylacetyl chloride
• Synonyms: 2-BroMo-2-cyclohexylacetyl chloride
• CAS NO: 90085-61-3
• Molecular Formula: C₈H₁₂BrClO
• Molecular Weight: 239.53728
• Mol File: 90085-61-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BroMo-2-cyclohexylacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-2-cyclohexylacetyl chloride(90085-61-3)
• EPA Substance Registry System: 2-BroMo-2-cyclohexylacetyl chloride(90085-61-3)

Safety Data

• Hazardous Substances Data: 90085-61-3(Hazardous Substances Data)

Upstream product

• 23860-35-7 cyclohexylacetic acid chloride 
• 5292-21-7 Cyclohexylacetic acid 

Downstream Products

• 1162677-57-7 2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-N-trans-(4-hydroxy-cyclohexyl)-acetamide 
• 1162677-43-1 2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-N-[2-fluoro-4-(1H-tetrazol-5-yl)-phenyl]-acetamide 
• 1162675-66-2 [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid 
• 1162676-07-4 [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid 
• 1162676-06-3 [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester 
• 1162675-80-0 [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester 
• 327985-56-8 3-cyclohexyl-8-(2-fluorophenyl)-5-methyl-2-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)imidazo[1,2-d][1,2,4]triazine 
• 92250-42-5 2-cyclohexyl-4H-benzo[1,4]oxazin-3-one 
• 900535-69-5 1-[(1-(4-chloro-benzyl)-2-{4-[1-cyclohexyl-2-(2,5-dioxo-pyrrolidin-1-yl)-ethyl]-piperazin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 900535-67-3 1-[(1-(4-chloro-benzyl)-2-{4-[1-cyclohexyl-2-(ethyl-methanesulfonyl-amino)-ethyl]-piperazin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 900535-68-4 1-{[2-{4-[2-(acetyl-ethyl-amino)-1-cyclohexyl-ethyl]-piperazin-1-yl}-1-(4-chloro-benzyl)-2-oxo-ethylcarbamoyl]-methyl}-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 900535-66-2 1-({1-(4-chloro-benzyl)-2-[4-(1-cyclohexyl-2-methanesulfonylamino-ethyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 900535-57-1 3-{1-(4-chloro-benzyl)-2-[4-(1-cyclohexyl-2-diethylamino-ethyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 900535-61-7 1-({1-(4-chloro-benzyl)-2-[4-(1-cyclohexyl-2-diethylamino-ethyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties

Structure-guided lead optimization of recently described benzimidazolyl acetamides addressed the key liabilities of the previous lead compound 1. These efforts culminated in the discovery of 4-{(S)-2-[2-(4-chloro-phenyl)-5,6- difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid 7g, a highly potent and selective FXR agonist with excellent physicochemical and ADME properties and potent lipid lowering activity after oral administration to LDL receptor deficient mice.