9010-02-0Relevant academic research and scientific papers
Practical catalytic nitration directly with commercial nitric acid for the preparation of aliphatic nitroesters
An, Jichao,He, Pan,Li, Wenhao,Liu, Peipei,Si, Mengyuan,Yang, Bo,Yang, Guanyu
supporting information, p. 6612 - 6616 (2020/09/21)
To pursue a sustainable and efficient approach for aliphatic nitroester preparation from alcohol, europium-triflate-catalyzed nitration, which directly uses commercial nitric acid, has been successfully developed. Gram scalability with operational ease showed its practicability.
Continuous production nitroglycerin tablet (by machine translation)
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Paragraph 0070-0073, (2020/08/27)
To specific processes of continuous production of raw materials of nitroglycerin and continuous production of tablets, green, safe and no-risk synthesis is achieved in the continuous production of the green preparation of the nitroglycerin, and the combined API and the nitroglycerin tablet are integrated. (by machine translation)
External preparation for nitroglycerin (by machine translation)
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Paragraph 0078-0088, (2020/09/04)
API and nitroglycerin external preparation integrated production is realized, the safety is improved, the impurity content is reduced, the environment is protected, and waste emission is reduced. (by machine translation)
Methods of producing glycidyl nitrate
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Page/Page column 14; 15, (2020/03/04)
Methods of producing glycidyl nitrate. The method comprises reacting glycerol and nitric acid in a microfluidic reactor to form a nitrated glycerol compound. The microfluidic reactor comprises a reaction volume of the microfluidic reactor of less than about 20 ml and an inner diameter of a reaction channel of the microfluidic reactor of less than or equal to about 1000 μm. The nitrated glycerol compound is reacted with a base in the microfluidic reactor to form glycidyl nitrate. Additional methods of producing glycidyl nitrate are also disclosed.
Low hazard small-scale synthesis and chemical analysis of high purity nitroglycerine (NG)
Contini, Alessandro E.,Flood, Nathan,McAteer, Daniel,Mai, Nathalie,Akhavan, Jacqueline
, p. 87228 - 87232 (2015/11/09)
A previously reported two-phase (99.5% fuming nitric acid/dichloromethane) batch method to prepare high purity 1,2,3-propanetriyl trinitrate (nitroglycerine, NG) was evaluated, simplified and adapted specifically for low hazard small-scale synthesis. The purity of the product, as determined by NMR spectroscopy, HPLC and IR spectroscopic analysis was found to be greater than 99%. The quick synthetic method is highly recommended when small amounts of highly pure NG are required for analytical and related purposes in the absence of a microreactor.
Synthesis of nitric acid esters from alcohols in a dinitrogen pentoxide/carbon dioxide liquid system
Kuchurov, Ilya V.,Fomenkov, Igor V.,Zlotin, Sergei G.,Tartakovsky, Vladimir A.
experimental part, p. 67 - 69 (2012/07/02)
Organic nitric acid esters have been prepared in 89-98% yield by the nitration of the corresponding alcohols and polyols with N2O5 in liquid CO2.
METHODS OF PRODUCING NITRATE ESTERS
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Page/Page column 5, (2012/06/01)
Methods of forming a nitrate ester include combining at least one nitrate salt and sulfuric acid to form a nitrating solution and adding an aliphatic polyol to the nitrating solution. Nitrate esters formed by this method may be, for example, triethylene glycol dinitrate (TEGDN), pentaerythritol tetranitrate (PETN), diglycerol tetranitrate (DGTN), 1,1,1-tris(methylol)ethane trinitrate (TMETN), 1,2,4-butanetriol trinitrate (BTTN), nitroglycerin (NG), diethylene glycol dinitrate (DEGDN), ethylene glycol dinitrate (EGDN), metriol trinitrate (MTN), nitrocellulose (NC), or 1,2-propanediol dinitrate (PDDN).
VASODILATOR-ENHANCED CARDIOPULMONARY RESUSCITATION
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, (2012/08/27)
A method for increasing blood flow to vital organs during cardiopulmonary resuscitation of a person experiencing a cardiac arrest may include performing standard or active compression decompression cardiopulmonary resuscitation on a person to create artificial circulation by repetitively compressing the person's chest such that the person's chest is subject to a compression phase and a relaxation or decompression phase. The method may also include administering one or more vasodilator drugs to the person to improve the artificial circulation created by the cardiopulmonary resuscitation. The method may also include binding at least a portion of the person's abdomen, either manually or with an abdominal compression device. Performing cardiopulmonary resuscitation on a person may include ventilating the person with either an impedance threshold device or a intrathoracic pressure regulator.
METHOD FOR THE PRODUCTION OF LIQUID NITRATE ESTERS
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Page/Page column 5-7, (2008/06/13)
The invention relates to a method for the production of liquid nitrate esters, e.g. nitro-glycerine, wherein an alcohol is esterified by means of nitrating acid and the reaction takes place in one or several microreactors.
BUCCAL, NON-POLAR SPRAY FOR NITROGLYCERIN
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, (2008/06/13)
A buccal aerosol spray using a non-polar solvent has now been developed which provides nitroglycerin for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal aerosol spray of the invention comprises: propellant 50-95%, non-polar solvent 5-50%, nitroglycerin 0.001-15%, flavoring agent 0.05-5%.
