90136-68-8Relevant academic research and scientific papers
Effect of stilbene and chalcone scaffolds incorporation in clofibric acid on PPARα agonistic activity
Giampietro, Letizia,D'Angelo, Alessandra,Giancristofaro, Antonella,Ammazzalorso, Alessandra,De Filippis, Barbara,Di Matteo, Mauro,Fantacuzzi, Marialuigia,Linciano, Pasquale,Maccallini, Cristina,Amoroso, Rosa
, p. 59 - 65 (2014/01/17)
In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, new compounds based on a combination of clofibric acid, the active metabolite of clofibrate, and trans-stilbene, chalcone, and other lipophilic groups were synthesized. They were evaluated for PPARα transactivation activity; all branched derivatives showed an increase of the transcriptional activity of receptor compared to the linear ones. Noteworthy, stilbene and benzophenone branched derivatives activated the PPARα better than clofibric acid.
Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetes
Christiansen, Elisabeth,Urban, Christian,Merten, Nicole,Liebscher, Kathrin,Karlsen, Kasper K.,Hamacher, Alexandra,Spinrath, Andreas,Bond, Andrew D.,Drewke, Christel,Ullrich, Susanne,Kassack, Matthias U.,Kostenis, Evi,Ulven, Trond
supporting information; experimental part, p. 7061 - 7064 (2009/11/30)
A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA1) has been discovered and explored. The preferred compound 20 (TUG-424, EC50 = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity.
Quality control method for manufacturing nucleic acid arrays
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, (2008/06/13)
The invention relates to a quality control method for manufacturing biopolymer arrays comprising the use of detectable protecting groups.
