90151-10-3

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Methoxy-pyridine-2-carboxylic acid amide is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the creation of diverse drug molecules, contributing to the development of new treatments for a range of medical conditions.
Used in Agrochemical Production:
In the agrochemical industry, 4-Methoxy-pyridine-2-carboxylic acid amide is employed as a precursor in the production of pesticides and other crop protection agents. Its functional groups facilitate the formation of active ingredients that can effectively control pests and diseases in agriculture.
Used as a Building Block for Complex Compounds:
Due to its reactive functional groups, 4-Methoxy-pyridine-2-carboxylic acid amide is used as a building block for the synthesis of more complex organic compounds. This allows for the development of advanced materials and specialty chemicals with specific properties and applications.
Used as a Ligand for Metal Complexes:
4-Methoxy-pyridine-2-carboxylic acid amide has potential applications as a ligand in the formation of metal complexes. These complexes can be used in various fields, including catalysis, where they can enhance the efficiency of chemical reactions.
Safety Considerations:
It is crucial to handle 4-Methoxy-pyridine-2-carboxylic acid amide with care, as it may pose risks to human health and the environment. Proper safety measures should be implemented during its production, use, and disposal to minimize potential hazards.

InChI:InChI=1/C7H8N2O2/c1-11-5-2-3-9-6(4-5)7(8)10/h2-4H,1H3,(H2,8,10)

Upstream product

• 29681-43-4 methyl 4-methoxypicolinate 
• 620-08-6 4-methoxypyridine 
• 77287-34-4 formamide 
• 29082-91-5 4-methoxypyridine-2-carboxylic acid 

Downstream Products

• 10201-73-7 2-amino-4-methoxypyridine 

Relevant academic research and scientific papers

Synthesis method of imidazopyridine or pyrimidine derivative

The invention belongs to the technical field of synthesis, and particularly relates to a synthesis method of an imidazopyridine or pyrimidine derivative. The imidazopyridine or pyrimidine compound is obtained by taking pyridine or pyrimidinecarboxylic acid as a synthon through amidation, Hofmann degradation and cyclization reaction, and the obtained imidazopyridine or pyrimidine derivative can be further converted to generate a functional product. The method has the advantages of easily available raw materials, simple operation, high reaction efficiency, convenient post-treatment, and diversity of functional groups.

Acid-Free Silver-Catalyzed Cross-Dehydrogenative Carbamoylation of Pyridines with Formamides

Primary pyridylcarboxamides are prevalent parent structures in bioactive molecules and have the apparent advantages over N-protected derivatives as synthetic building blocks. However, no practical methods have been developed for direct synthesis of this compound class from unfunctionalized pyridines. We herein present a general, safe, concise, acid-free, and highly selective method for the C2-carbamoylation of pyridines with unprotected formamide and N-methyl formamide through the cleavage of two C-H bonds.

Method for synthesizing pyridine primary amides by direct catalytic oxidation process

The invention discloses a method for synthesizing pyridine primary amides by a direct catalytic oxidation process. The method comprises the following steps: under the action of acid or alkali, adding an accelerator water and an oxidizer into formamide which is used as a carbonyl source and nitrogen source, and catalytically oxidizing double C-H bonds of pyridine or derivatives thereof under the action of a silver and/or iron catalyst to directly prepare the pyridine primary amides. By activating the double C-H bonds, the method disclosed by the invention has the advantages of ideal atomic economy, less generated waste, wide and stable substrate sources, and low price. Under the optimized reaction conditions, the separation yield of the target products is up to 98%.

Cyclic ureas as ortho directing substituents

Six-membered cyclic ureas are shown to have a weak ortho directing ability when linked through nitrogen to benzene and pyridine rings.