90196-32-0 Usage
Uses
Used in Pharmaceutical Industry:
2-Chloro-5-ethyl-pyridine is used as a key intermediate in the synthesis of biologically active compounds, specifically for the preparation of potential vanilloid receptor-1 (VR1) antagonists. These antagonists are valuable in the development of drugs targeting pain relief and other therapeutic applications, as they can modulate the activity of the VR1 receptor, which plays a crucial role in pain perception and inflammatory responses.
Check Digit Verification of cas no
The CAS Registry Mumber 90196-32-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,1,9 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 90196-32:
(7*9)+(6*0)+(5*1)+(4*9)+(3*6)+(2*3)+(1*2)=130
130 % 10 = 0
So 90196-32-0 is a valid CAS Registry Number.
InChI:InChI=1S/C7H8ClN/c1-2-6-3-4-7(8)9-5-6/h3-5H,2H2,1H3
90196-32-0Relevant academic research and scientific papers
A 2 - chloro - 5 - ethyl pyridine preparation method (by machine translation)
-
Paragraph 0019; 0037; 0038, (2017/08/25)
The invention discloses a method for synthesizing 2 - chloro - 5 - ethyl pyridine method, by Suzuki reaction with 2 - chloro - 5 - bromo pyridine or by Wittig reaction with 2 - chloro - 5 - formyl pyridine is converted into 2 - chloro - 5 - vinyl pyridine; further uses the type (I) selective hydrogenation catalyst-containing structure, wherein R is cyclohexyl, butyl or phenyl, L is pyridine or unsaturated including nitrogen Cabeen, the 2 - chloro - 5 - vinyl pyridine is converted into 2 - chloro - 5 - ethyl pyridine. The method of the invention has a high selectivity, high yield and the advantage of convenient purification. (by machine translation)
