90196-34-2

Basic information

• Product Name: 2-chloro-5-(hydroxymethyl)Benzenesulfonamide
• Synonyms: 2-chloro-5-(hydroxymethyl)Benzenesulfonamide
• CAS NO: 90196-34-2
• Molecular Formula: C₇H₈ClNO₃S
• Molecular Weight: 221.66132
• Mol File: 90196-34-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-5-(hydroxymethyl)Benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-(hydroxymethyl)Benzenesulfonamide(90196-34-2)
• EPA Substance Registry System: 2-chloro-5-(hydroxymethyl)Benzenesulfonamide(90196-34-2)

Safety Data

• Hazardous Substances Data: 90196-34-2(Hazardous Substances Data)

Upstream product

• 1211-77-4 3-sulfamoyl-4-chlorobenzoic acid ethyl ester 
• 1205-30-7 4-chloro-3-sulphamoylbenzoic acid 
• 2494-79-3 4-chloro-3-(chlorosulfonyl)benzoic acid 
• 74-11-3 para-chlorobenzoic acid 
• 1208-40-8 4-chloro-3-sulfamoylbenzoic acid methyl ester 

Downstream Products

• 3279-81-0 2-chloro-5-formyl-benzenesulphonamide 

Relevant articles and documents

Design, synthesis and SAR study of novel sulfonylureas containing an alkenyl moiety

A series of sulfonylurea compounds was designed and synthesized via introducing an alkenyl moiety into the aryl-5 position and most title compounds exhibited enhanced antifungal activities and limited herbicidal activities compared with chlorsulfuron. Then, a CoMSIA calculation for antifungal activities was carried out to establish a 3D-QSAR model in which a cross-validated q2 of 0.585 and a correlation coefficient r2 of 0.989 were obtained. The derived model revealed that hydrophobic and electrostatic fields were the two most important factors for antifungal activity. Structure optimization was performed according to the CoMSIA model and compound 9z was found to be as potent as chlorothalonil in vitro against C. cornigerum, the pathogen of the wheat sharp eyespot disease. In order to study the fungicidal mechanism, 9z was successfully docked into yeast AHAS using a flexible molecular docking method and the resulting binding pattern was similar to that of chlorimuron-ethyl, indicating that the antifungal activity of compounds 9 was probably due to the inhibition of fungal AHAS.

SYNTHETIC ANALOGUES OF XANTHOHUMOL

The present invention relates to novel synthetic analogues of xanthohumol and the use thereof.