90210-56-3Relevant academic research and scientific papers
Synthesis of Polysubstituted Isoquinolines and Related Fused Pyridines from Alkenyl Boronic Esters via a Copper-Catalyzed Azidation/Aza-Wittig Condensation Sequence
Jayaram, Vankudoth,Sridhar, Tailor,Sharma, Gangavaram V. M.,Berrée, Fabienne,Carboni, Bertrand
, p. 843 - 853 (2018/01/28)
An efficient and straightforward synthesis of isoquinolines is reported from internal alkenyl boronic esters, easily prepared from the corresponding 1,2-bis(boronates), via a sequential copper-catalyzed azidation/aza-Wittig condensation. This synthetic method has been used to synthesize quinisocaine, a topical anesthetic used for the treatment of pain and pruritus, and further extended to thieno[2,3-c]pyridines by using 2-thiophenecarboxaldehyde as coupling partner in the first step.
Synthesis of 3-benzylisoquinolines by domino imination/cycloisomerisation of 2-propargylbenzaldehydes
Dell'Acqua, Monica,Pirovano, Valentina,Confalonieri, Giorgio,Arcadi, Antonio,Rossi, Elisabetta,Abbiati, Giorgio
, p. 8019 - 8030 (2015/01/08)
An easy entry to uncommon 2-propargylbenzaldehydes was developed. 2-Propargylbenzaldehydes demonstrated to be suitable building blocks for the synthesis of 3-benzyl isoquinolines by microwave promoted domino imination/cycloisomerisation in the presence of
Facile synthesis of 3-substituted isoquinolines derivatives via microwave-assisted tandem three-component coupling cyclization
Lin, Long,Wu, Qiongyou,Huang, Shaowei,Yang, Guangfu
experimental part, p. 1075 - 1082 (2012/08/07)
A novel three-component reaction of o-bromobenzaldehyde, terminal alkynes and tert-butyl amine has been established, which proceeded smoothly to give 3-substituted isoquinolines in good yields in the presence of palladium/copper catalysts under microwave irradiation.
TETRAHYDROISOQUINOLINE COMPOUND
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Page/Page column 25-26, (2010/01/29)
The present invention relates a specific tetrahydroisoquinoline compound which is useful as a chemokine receptor type 3 (CCR3) antagonist, and a pharmaceutical composition comprising the same as an active ingredient. The tetrahydroisoquinoline compound of the present invention is useful for the treatment or prevention of a disease in which CCR3 participates.
INDOLOPYRIDINES WITH A HETERO ATOM AT A POSITION OF FUSION. 5. CATALYTIC SYNTHESIS OF INDOLOISOQUINOLINE BY PYROLYSIS OF BENZYLISOQUINOLINES
Soldatova, S.A.,Alarcon, J. A. Rodriguez,Soldatenkov, A. T.
, p. 69 - 72 (2007/10/02)
High-temperature heterocyclization of α-benzylisoquinolines on oxide-type catalysts gave angular indoloisoquinoline.
THERMOLYTIC RING OPENING OF ACYLOXYBENZOCYCLOBUTENES: AN EFFICIENT ROUTE TO 3-SUBSTITUTED ISOQUINOLINES
Schiess, Peter,Huys-Francotte, Martine,Vogel, Caspar
, p. 3959 - 3962 (2007/10/02)
Upon flash vacuum pyrolysis acyloxybenzocyclobutenes 4 rearrange through an intramolecular 1,5-acyl shift to 2-formylbenzyl ketones 6 which can be converted to 3-substituted isoquinolines 7.
Recyclization of 3-Alkyl- and 1,3-Dialkylisoquinolinium Salts to Naphthylamines
Kost, A. N.,Terenin, V. I.,Yudin, L. G.,Sagitullin, R. S.
, p. 965 - 969 (2007/10/02)
3-Methyl- and 3-benzylisoquinolinium salts undergo rearrangement to 2-alkylaminonaphthalenes under the influence of alcohol solutions of alkylamines.The rearrangement of 1,3-dimethyl- and 1-methyl-3-benzylisoquinolinium salts leads to both 1- and 2-alkylaminonaphthalenes with predominance of the former.
