90225-19-7Relevant articles and documents
N-Acylhydrazones as inhibitors of PDE10A
Gage, Jennifer L.,Onrust, Rene,Johnston, Derek,Osnowski, Andrew,MacDonald, Wendy,Mitchell, Lee,ür?gdi, László,Rohde, Alex,Harbol, Kevin,Gragerov, Sasha,Dormán, Gy?rgy,Wheeler, Tom,Florio, Vince,Cutshall, Neil S.
scheme or table, p. 4155 - 4159 (2011/08/10)
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.
Synthesis of 4- and 7-quinolinesulfonamides from 4,7-dichloroquinoline
Marciniec, Krzysztof,Maslankiewicz, Andrzej
scheme or table, p. 93 - 101 (2009/05/07)
Action of sodium methanethiolate (in boiling DMF) towards 4,7-dichloroquinoline (1) or 7-chloro-1-methyl-4(1H)-quinolinone (11) occured via chlorine ipso-substitution followed by methanethiolato-S-demethylation to yield dithiolate 1A or thiolate 18A, whic