90269-48-0

Upstream product

• 106-39-8 bromochlorobenzene 
• 5856-79-1 iso-butyl chloroformate 
• 56790-88-6 (Z)-1-(4-Chloro-phenyl)-2-methyl-but-2-en-1-one 
• 56790-89-7 (E)-1-(4-chlorophenyl)-2-methyl-2-buten-1-one 
• 598-30-1 sec.-butyllithium 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 
• 66534-32-5 α,α-diisopropyl-β-methylhomoallylic alcohol 
• 104-88-1 4-chlorobenzaldehyde 
• 92594-58-6 α-methoxy-p-chlorobenzylphosphonic acid diethyl ester 
• 56790-68-2 1-(4-Chloro-phenyl)-2-methyl-but-3-ene-1,2-diol 
• 74-11-3 para-chlorobenzoic acid 
• 74-88-4 methyl iodide 
• 14248-33-0 2-methyl-1-(4-chlorophenyl)butan-1-ol 

Relevant academic research and scientific papers

One-pot synthesis of α,α-disubstituted Aryl-1-ethanones via the Wittig-Horner reaction

A one-pot methodology for the synthesis of α,α-disubstituted aryl-1-ethanones via the Wittig-Horner reaction has been developed and described in this manuscript. Both aryl/alkyl and dialkyl α-branched arylethanone were obtained in high yields (up to 96%) without the use of any metal catalysts. A total of 14 α,α-disubstituted arylethanone derivatives were synthesized based on this simple method that easily converts the carbonyl carbon (sp2) into the sp3 carbon. This versatile method is expected to further promote the use of substituted ketones as synthetic building blocks to construct a variety of α-branched aryl ketones.

Rhodium-catalyzed allyl transfer from homoallyl alcohols to aldehydes via retro-allylation followed by isomerization into ketones

Retro-allylation of homoallyl alcohol by rhodium catalysis occurs to generate allylrhodium species. This allylrhodium reacts with aldehydes to give the corresponding secondary alcohols in situ. Isomerization of these alcohols proceeds in the same pots to furnish the corresponding saturated ketones in good yields.

The first regioselective metalation and functionalization of unprotected 4-halobenzoic acids

(Chemical Equation Presented) By treatment with s-BuLi, s-BuLi/TMEDA, or t-BuLi at ～-78°C, 4-fluoro- and 4-chlorobenzoic acids (1a,b) are metalated preferentially in the position adjacent to the carboxylate. A complete reversal in regioselectivity is observed for 1a when treated with LTMP; a sequential process involving a rapid intraaggregate lithiation through a quasi dianion complex "QUADAC" is postulated to explain the unusual reactivity of Me2S2 and I2.

One-pot synthesis of ketones using N-methoxy-N-methyl-2-pyridyl urethane

The one-pot reaction of N-methoxy-N-methyl-2-pyridyl urethane with Grignard and organolithium reagents provided an efficient method for the preparation of unsymmetrical ketones.

Kinetics and Mechanism of the Reaction of Ketones with Lithium Reagents in Cyclohexane

The kinetics of the reaction of sec-BuLi and n-BuLi with several substituted phenyl sec-butyl ketones in cyclohexane at 25.0 deg C have been examined by stopped-flow infrared spectroscopy.Experiments in which reacting solutions of the ketones were scanned