902779-63-9Relevant academic research and scientific papers
Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells
Barve, Vivek,Ahmed, Fakhara,Adsule, Shreelekha,Banerjee, Sanjeev,Kulkarni, Sudhir,Katiyar, Prashant,Anson, Christopher E.,Powell, Annie K.,Padhye, Subhash,Sarkar, Fazlul H.
, p. 3800 - 3808 (2006)
The synthesis and characterization of Schiff base derivatives of 3-formylchromone 3-6 (FPA-120 to FPA-123), the minimal biologically active structural motif of soy isoflavone, genistein, and their copper(II) complexes 7-10 (FPA-124 to FPA-127) are reporte
Novel hydrazine derivatives having PLK1 inhibition activity and use thereof
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Paragraph 0087; 0093; 0197; 0198, (2018/05/31)
The present invention relates to a novel hydrazine derivative having polo-like kinase 1 (PLK1) inhibitory activities, and a use thereof. More specifically, the compound, according to the invention, inhibits activities of PLK1 and suppresses proliferation of cancer cells. Thus, a pharmaceutical composition containing the same as an active ingredient can be useful for preventing or treating cancer.COPYRIGHT KIPO 2018
Hydrazide derivatives and anticancer agent comprising the same
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Paragraph 0148; 0152-0153; 0155, (2019/02/20)
The present invention relates to novel hydrazide derivatives, pharmaceutically-acceptable salt of the same, a pharmaceutical composition including the hydrazide derivatives for prevention and treatment of cancer, and a dietary supplement composition inclu
Synthesis, biological evaluation and molecular docking studies of chromone hydrazone derivatives as α-glucosidase inhibitors
Wang, Guangcheng,Chen, Ming,Wang, Jing,Peng, Yaping,Li, Luyao,Xie, ZhenZhen,Deng, Bing,Chen, Shan,Li, Wenbiao
supporting information, p. 2957 - 2961 (2017/05/31)
A series of chromone hydrazone derivatives 4a–4p have been synthesized, characterized by 1H NMR and 13C NMR and evaluated for their?in?vitro α-glucosidase inhibitory activity. Out of these tested compounds, six (4a, 4b, 4d, 4j, 4o and 4p) displayed potent α-glucosidase inhibitory activity with IC50 values in the range of 20.1?±?0.19?μM to 45.7?±?0.23?μM, as compared to the standard drug acarbose (IC50?=?817.38?±?6.27?μM). Among this series, compound 4d (IC50?=?20.1?±?0.19?μM) with 4-sulfonamide substitution at phenyl part of hydrazide was found to be the most active compound. Lineweaver-Burk plot analysis indicated that compound 4d is a non-competitive inhibitor of α-glucosidase. The binding interactions of the most active analogs were confirmed through molecular docking studies. Docking studies showed 4d are interacting with the residues Glu-276, Asp-214, Asp-349 and Arg-439 through hydrogen bonds, arene-anion and arene-cation interactions. In summary, our studies shown that these chromone hydrazone derivatives are a new class of α-glucosidase inhibitors.
