90290-83-8

Upstream product

• 64480-70-2 N-(4-cyanobenzoyl)glycine methyl ester 
• 619-65-8 4-cyanobenzoic Acid 
• 56-40-6 glycine 
• 99300-38-6 4-cyanobenzoic acid N-hydroxysuccinimide ester 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 61-78-9 p-Aminohippuric acid 

Downstream Products

• 425380-47-8 (Z)-2-(p-cyanobenzoylamino)-N-(3'-dimethylaminopropyl)-3-(1-naphthyl)-2-propenamide 
• 800393-92-4 (Z)-2-(4-cyanobenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide 
• 425380-65-0 (Z)-2-(p-cyanophenyl)-4-(1-naphthylmethylene)-5(4H)-oxazolone 
• 90290-84-9 4-Benzyliden-2-(4-cyanphenyl)oxazolin-5-on 

Relevant academic research and scientific papers

Addressing hERG activity while maintaining favorable potency, selectivity and pharmacokinetic properties of PPARδ modulators

One of the most commonly used strategies to reduce hERG (human ether-a-go-go) activity in the drug candidates is introduction of a carboxylic acid group. During the optimization of PPARδ modulators, some of the compounds containing a carboxylic acid were found to inhibit the hERG channel in a patch clamp assay. By modifying the basicity of the imidazole core, potent and selective PPARδ modulators that do not inhibit hERG channel were identified. Some of the modulators have excellent pharmacokinetic profiles in mice.

Unsaturated oxazolones as nonlinear fluorophores

Unwanted bleaching of two-photon absorption microscopy probes can be reduced by designing more efficient nonlinear fluorophores. Here the linear and nonlinear photophysical properties of unsaturated oxazolones are studied. A set of push-pull oxazolone der

Method for binding albumin and means to be used in the method

A method for binding albumin by contacting an aqueous liquid containing an albumin with an albumin-binding compound is selected from albumin-binding compounds containing the scaffold --CO--NH--C(=C--)--CO--, and conjugates that are capable of binding albumin and exhibiting the scaffold --CO--NH--C(=C--)--CO--.