90301-60-3

Usage

Uses

Used in Antiviral Applications:
5-(2-Hydroxyethyl)-2'-deoxyuridine is used as a potent antiviral agent for its ability to inhibit viral replication and activity. It targets specific viral enzymes or processes, thereby preventing the virus from multiplying and spreading within the host organism. This makes it a valuable tool in the treatment and management of various viral infections.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-(2-Hydroxyethyl)-2'-deoxyuridine is utilized as a key component in the development of antiviral drugs. Its unique structure and antiviral properties make it an attractive candidate for the creation of new medications aimed at treating a wide range of viral diseases.
Used in Research and Development:
5-(2-Hydroxyethyl)-2'-deoxyuridine is also used as a research compound in the field of virology and medicinal chemistry. Scientists and researchers employ this nucleoside analog to study the mechanisms of viral replication, drug resistance, and the development of novel antiviral therapies. Its use in research contributes to a deeper understanding of viral pathogens and the advancement of antiviral treatments.

Upstream product

• 624-76-0 Iodoethanol 
• 951-78-0 2'-deoxyuridine 
• 90301-69-2 5-(2-chloroethyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 51432-34-9 1-(O³,O⁵-bis-trimethylsilanyl-β-D-erythro-2-deoxy-pentofuranosyl)-4-trimethylsilanyloxy-1H-pyrimidin-2-one 

Downstream Products

• 352353-42-5 acetic acid 8-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-8,13,15-trioxo-7,9,17-trioxa-1,14-diaza-8λ⁵-phospha-tricyclo[10.3.1.1^2,5]heptadec-12(16)-en-4-yl ester 
• 352320-16-2 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-5-[2-(4,4'-dimethoxytrityloxy)ethyl]-2'-deoxyuridine 
• 352320-15-1 5'-O-(4,4'-dimethoxytrityl)-5-[2-(4,4'-dimethoxytrityloxy)ethyl]-2'-deoxyuridine 
• 97975-03-6 1-(5-bromo-2,5-dideoxy-β-D-erythro-pentofuranosyl)-5-(2-bromoethyl)-1H,3H-pyrimidine-2,4-dione 
• 90301-64-7 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2-bromoethyl)pyrimidine-2,4(3H)dione 
• 90301-59-0 5-(2-chloroethyl)-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 97975-02-5 1-(5-chloro-2,5-dideoxy-β-D-erythro-pentofuranosyl)-5-(2-chloroethyl)-1H,3H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Essential factors for stabilization of the predominant C3′-endo conformation in dinucleoside phosphotriester derivatives with cyclonucleotide bridge structures at the downstream 3′-position

This paper describes the synthesis of conformationally constrained dinucleoside cyclic phosphotriester derivatives and related compounds, such as Tpc3Um (2), Tpc3dU (3), Tpc2dU (4), pc3dU (16), and pc2dU (25), where c2 and c3 refer to ethylene and propyle

Photochemical synthesis of 5-alkylpyrimidine nucleosides

5-Alkylpyrimidine nucleosides, bearing different functional groups attached to the newly formed carbon chains at C-5, were synthesized via a photocoupling reaction, 5-(2-Hydroxyethyl)uridine and its derivatives were obtained from the reaction of uridine (U) or 2'deoxyuridine (DU) with 2-iodoethanol.Trimethylsilyl derivatives of 5-iodouridine (IU) and 5-iodo-2'-deoxyuridine (IDU), when treated with methyl acrylate, gave methyl 3-(5-uridinyl)propenoate and methyl 3-(2'-deoxy-5-uridinyl) propenoate, respectively, which, upon catalytic hydrogenation, afforded 5-uridine and its 2-deoxyuridine analogue.IU and IDU also gave 5-(2-cyanoethenyl)uridine and its 2'-deoxyuridine analogue, when treated with acrylonitrile.The latter compounds gave the corresponding 5-(2-cyanoethyl) nucleosides when subjected to catalytic hydrogenation.

5-(Haloalkyl)-2'-deoxyuridines: A Novel Type of Potent Antiviral Nucleoside Analogue

Syntheses of 5-(2-haloethyl)-2'-deoxyuridines, 5-(3-chloropropyl)-2'-deoxyuridines, and 5-(2-chloroethyl)-2'-deoxycytidine are described.The antiviral activities of these compounds were determined in cell culture against herpes simplex virus types 1 and 2