90328-72-6 Usage
Explanation
This is the chemical name of the compound, which is also known as CQET.
Explanation
CQET has been studied for its potential to inhibit the growth of cancer cells and suppress the replication of the malaria parasite.
Explanation
CQET is derived from quinoline, a heterocyclic compound found in certain natural products and pharmaceuticals.
Explanation
CQET has been shown to inhibit ribonucleotide reductase, an enzyme necessary for DNA synthesis and cell proliferation.
Explanation
By inhibiting ribonucleotide reductase, CQET can potentially suppress tumor growth and malaria parasite replication.
Explanation
CQET has been investigated for its ability to induce oxidative stress and inhibit angiogenesis, making it a promising candidate for further research and development in cancer and malaria treatment.
Potential Activities
Antineoplastic and anti-malarial
Chemical Derivation
Quinoline derivative
Target Enzyme
Ribonucleotide reductase
Mechanism of Action
Inhibition of DNA synthesis and cell proliferation
Additional Properties
Induction of oxidative stress and inhibition of angiogenesis
Check Digit Verification of cas no
The CAS Registry Mumber 90328-72-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,3,2 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 90328-72:
(7*9)+(6*0)+(5*3)+(4*2)+(3*8)+(2*7)+(1*2)=126
126 % 10 = 6
So 90328-72-6 is a valid CAS Registry Number.
90328-72-6Relevant academic research and scientific papers
2-Acetylpyridine thiosemicarbazones. 7. Derivatives of 2-acetylquinoline as potential antimalarial agents
Klayman,Scovill,Bartosevich,et al.
, p. 49 - 53 (2007/10/02)
A series of 2-acetylquinoline thiosemicarbazones with potential antimalarial properties was prepared by the reaction of methyl hydrazinecarbodithioate with 2-acetylquinoline to afford methyl 3-[1-(2-quinolyl)ethylidene]hydrazinecarbodithioate (II). Displacement of the S-methyl group of the latter compound by amines gave the desired 2-acetylquinoline thiosemicarbazones (III). Related thiosemicarbazides were obtained by reduction of the azomethine group of II with sodium borohydride to give methyl 3-[1-(2-quinolyl)ethyl]hydrazinecarbodithioate (IV). The S-methyl group of IV was displaced by amines resulting in the formation of 1-[1-(2-quinolyl)ethyl]thiosemicarbazides (V). Evaluation of the antimalarial activity of compound types III and V, performed in mice infected with Plasmodium berghei, showed that most of the test compounds effected cures in the dose range of 320-640 mg/kg.
