90329-77-4Relevant academic research and scientific papers
α-C-H/N-H Annulation of Alicyclic Amines via Transient Imines: Preparation of Polycyclic Lactams
Chen, Weijie,Seidel, Daniel
supporting information, p. 3729 - 3734 (2021/05/31)
Polycyclic lactams are prepared in a single operation from o-toluamides and cyclic amines in a process that involves transient cyclic imines, species that are conveniently obtained in situ from the corresponding lithium amides and simple ketone oxidants. Imines thus generated, such as 1-pyrroline and 1-piperideine, engage lithiated o-toluamides in a facile annulation process. Undesired side reactions such as imine deprotonation and o-toluamide dimerization are suppressed through the judicious choice of reaction conditions.
A CONVENIENT SYNTHESIS OF 1-AZABICYCLOALKANES AND THEIR LACTAMS VIA CUPRATES OF FORMAMIDINES
Edwards, Philip D.,Meyers, A. I.
, p. 939 - 942 (2007/10/02)
Piperidine and pyrrolidine formamidines, transformed into their α-metalloderivatives are alkylated with bifunctional electrophiles and cyclized, on formamidine removal, to the title compounds.
